MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 18 to 67 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.1243	Zinc finger protein basonuclin-2. [Uniprot/SWISSPROT;Acc:Q6ZN30]	cellular component	nucleus
		molecular function	DNA binding
			metal ion binding
			nucleic acid binding
			zinc ion binding
1.13541	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435]	biological process	blood coagulation
			cell adhesion
			regulation of growth
		cellular component	extracellular region
			membrane
		molecular function	calcium ion binding
			protein binding
			structural molecule activity
			transmembrane receptor activity
1.14311	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	biological process	negative regulation of protein kinase activity
			protein targeting
			regulation of neuron differentiation
			regulation of signal transduction
			regulation of synaptic plasticity
		cellular component	cytoplasm
		molecular function	insulin-like growth factor receptor binding
			protein domain specific binding
			protein kinase C binding
			protein kinase C inhibitor activity
1.1611	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	biological process	electron transport
			signal transduction
		cellular component	extracellular region
		molecular function	electron carrier activity
			enzyme activator activity
			guanylate cyclase activator activity
			hormone activity
1.17859	XK-related protein 5. [Uniprot/SWISSPROT;Acc:Q6UX68]	cellular component	integral to membrane
			membrane
1.18096	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	biological process	anagen
			blood pressure regulation
			cell motility
			cyclooxygenase pathway
			electron transport
			fatty acid biosynthetic process
			negative regulation of cell proliferation
			regulation of inflammatory response
			regulation of progression through cell cycle
			response to oxidative stress
		cellular component	caveolar membrane
			cytoplasm
			endoplasmic reticulum
			membrane
			microsome
			nucleus
			protein complex

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.