MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 169 to 218 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.17398	up	Ectonucleoside triphosphate diphosphohydrolase 5 precursor (EC 3.6.1.6) (NTPDase 5) (Nucleoside diphosphatase) (CD39 antigen-like 4) (ER-UDPase). [Uniprot/SWISSPROT;Acc:O75356]	cellular component	endoplasmic reticulum
				integral to membrane
				membrane
			molecular function	calcium ion binding
				hydrolase activity
				magnesium ion binding
				nucleoside-diphosphatase activity
1.17693		Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Uniprot/SWISSPROT;Acc:Q9H4M7]	biological process	biological_process
			cellular component	cellular_component
				cytoplasm
				membrane
			molecular function	lipid binding
				phosphatidylinositol binding
1.17859	down	XK-related protein 5. [Uniprot/SWISSPROT;Acc:Q6UX68]	cellular component	integral to membrane
				membrane
1.17879	up	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4). [Uniprot/SWISSPROT;Acc:P56696]	biological process	inner ear morphogenesis
				ion transport
				potassium ion transport
				sensory perception of sound
			cellular component	membrane
				membrane fraction
				voltage-gated potassium channel complex
			molecular function	ion channel activity
				potassium ion binding
				voltage-gated ion channel activity
				voltage-gated potassium channel activity
1.18096	down	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	biological process	anagen
				blood pressure regulation
				cell motility
				cyclooxygenase pathway
				electron transport
				fatty acid biosynthetic process
				negative regulation of cell proliferation
				regulation of inflammatory response
				regulation of progression through cell cycle
				response to oxidative stress
			cellular component	caveolar membrane
				cytoplasm
				endoplasmic reticulum
				membrane
				microsome
				nucleus
				protein complex
			molecular function	heme binding
				iron ion binding
				metal ion binding
				oxidoreductase activity
				oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
				peroxidase activity
				prostaglandin-endoperoxide synthase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.