MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Accession	Class	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 169 to 218 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.17398	up	Ectonucleoside triphosphate diphosphohydrolase 5 precursor (EC 3.6.1.6) (NTPDase 5) (Nucleoside diphosphatase) (CD39 antigen-like 4) (ER-UDPase). [Uniprot/SWISSPROT;Acc:O75356]	calcium ion binding	molecular function
			endoplasmic reticulum	cellular component
			hydrolase activity	molecular function
			integral to membrane	cellular component
			magnesium ion binding	molecular function
			membrane	cellular component
			nucleoside-diphosphatase activity	molecular function
1.17693		Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Uniprot/SWISSPROT;Acc:Q9H4M7]	biological_process	biological process
			cellular_component	cellular component
			cytoplasm
			lipid binding	molecular function
			membrane	cellular component
			phosphatidylinositol binding	molecular function
1.17859	down	XK-related protein 5. [Uniprot/SWISSPROT;Acc:Q6UX68]	integral to membrane	cellular component
			membrane
1.17879	up	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4). [Uniprot/SWISSPROT;Acc:P56696]	inner ear morphogenesis	biological process
			ion channel activity	molecular function
			ion transport	biological process
			membrane	cellular component
			membrane fraction
			potassium ion binding	molecular function
			potassium ion transport	biological process
			sensory perception of sound
			voltage-gated ion channel activity	molecular function
			voltage-gated potassium channel activity
			voltage-gated potassium channel complex	cellular component
1.18096	down	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	anagen	biological process
			blood pressure regulation
			caveolar membrane	cellular component
			cell motility	biological process
			cyclooxygenase pathway
			cytoplasm	cellular component
			electron transport	biological process
			endoplasmic reticulum	cellular component
			fatty acid biosynthetic process	biological process
			heme binding	molecular function
			iron ion binding
			membrane	cellular component
			metal ion binding	molecular function
			microsome	cellular component
			negative regulation of cell proliferation	biological process
			nucleus	cellular component
			oxidoreductase activity	molecular function
			oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
			peroxidase activity
			prostaglandin-endoperoxide synthase activity
			protein binding
			protein complex	cellular component
			regulation of inflammatory response	biological process
			regulation of progression through cell cycle

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.