MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1601 to 1650 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
1.33329	Beta-mannosidase precursor (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase). [Uniprot/SWISSPROT;Acc:O00462]	cellular component	lysosome
		molecular function	beta-mannosidase activity
			cation binding
			hydrolase activity, hydrolyzing O-glycosyl compounds
1.33465	T-box transcription factor TBX5 (T-box protein 5). [Uniprot/SWISSPROT;Acc:Q99593]	biological process	cell-cell signaling
			embryonic arm morphogenesis
			embryonic limb morphogenesis
			forelimb morphogenesis
			heart development
			induction of apoptosis
			lung development
			morphogenesis of an epithelium
			multicellular organismal development
			negative regulation of cardiac muscle cell proliferation
			negative regulation of cell migration
			pattern specification process
			pericardium development
			positive regulation of cardioblast differentiation
			positive regulation of transcription from RNA polymerase II promoter
			positive regulation of transcription, DNA-dependent
			regulation of transcription, DNA-dependent
			transcription
		cellular component	cytoplasm
			nucleus
		molecular function	protein binding
			RNA polymerase II transcription factor activity
			sequence-specific DNA binding
			transcription factor activity
			transcriptional activator activity
1.34001	Protein DmX-like 2 (Rabconnectin-3). [Uniprot/SWISSPROT;Acc:Q8TDJ6]	cellular component	cell junction
			cytoplasmic vesicle
			membrane
			synapse
			synaptic vesicle
		molecular function	Rab GTPase binding
1.34491	Bardet-Biedl syndrome 5 protein. [Uniprot/SWISSPROT;Acc:Q8N3I7]	biological process	response to stimulus
			visual perception
		cellular component	cellular_component
			cilium
			intracellular
		molecular function	molecular_function
1.34969	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10). [Uniprot/SWISSPROT;Acc:P27448]	biological process	protein amino acid phosphorylation
		molecular function	ATP binding
			nucleotide binding
			protein binding
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
1.35022	N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. [Uniprot/SWISSPROT;Acc:O15527]	biological process	base-excision repair

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.