MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1569 to 1618 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.78439	up	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]	DNA binding	molecular function
			helicase activity
			hydrolase activity
			intracellular signaling cascade	biological process
			metal ion binding	molecular function
			nucleic acid binding
			nucleotide binding
			nucleus	cellular component
			protein binding	molecular function
			regulation of transcription from RNA polymerase II promoter	biological process
			transcription
			transcription factor binding	molecular function
			zinc ion binding
1.78708		Centromere protein L (CENP-L) (Interphase centromere complex protein 33). [Uniprot/SWISSPROT;Acc:Q8N0S6]	chromosome	cellular component
			chromosome, pericentric region
			nucleus
1.79094		Protein FAM65A. [Uniprot/SWISSPROT;Acc:Q6ZS17]	binding	molecular function
			intracellular	cellular component
			signal transduction	biological process
1.7961		RAS-like, family 11, member A [RefSeq_peptide;Acc:NP_996563]	GTP binding	molecular function
			intracellular	cellular component
			nucleotide binding	molecular function
			protein transport	biological process
			small GTPase mediated signal transduction
1.80858	down	Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]	intracellular	cellular component
			protein binding	molecular function
			signal transduction	biological process
			small GTPase regulator activity	molecular function
1.80942		Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]	integral to membrane	cellular component
			membrane
1.81557		Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]	ATP binding	molecular function
			DNA binding
			helicase activity
			homoiothermy	biological process
			hydrolase activity	molecular function
			ice binding
			nucleic acid binding
			nucleotide binding
			nucleus	cellular component
			response to freezing	biological process
1.82063		Transmembrane protein 116. [Uniprot/SWISSPROT;Acc:Q8NCL8]	integral to membrane	cellular component
			membrane
1.82311		Fibroblast growth factor 5 precursor (FGF-5) (HBGF-5) (Smag-82). [Uniprot/SWISSPROT;Acc:P12034]	cell proliferation	biological process
			cell-cell signaling
			extracellular space	cellular component
			fibroblast growth factor receptor signaling pathway	biological process
			glial cell differentiation
			growth factor activity	molecular function
			nervous system development	biological process
			regulation of progression through cell cycle

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.