MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Regulation	Ratio	Gene Ontology	description	Class	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1569 to 1618 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
1.30407	axonogenesis	Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H). [Uniprot/SWISSPROT;Acc:O15522]	biological process
	multicellular organismal development
	nucleus		cellular component
	regulation of transcription, DNA-dependent		biological process
	RNA polymerase II transcription factor activity		molecular function
	sequence-specific DNA binding
	transcription factor activity
	transcription from RNA polymerase II promoter		biological process
1.31661	anion exchanger activity	Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879]	molecular function
	anion transport		biological process
	antiporter activity		molecular function
	apical plasma membrane		cellular component
	brush border membrane
	chloride ion binding		molecular function
	cytochrome complex assembly		biological process
	excretion
	heme transport
	heme transporter activity		molecular function
	integral to membrane		cellular component
	membrane
	membrane fraction
	sulfate porter activity		molecular function
	sulfate transport		biological process
	transcription cofactor activity		molecular function
	transcription factor activity
	transport		biological process
	transporter activity		molecular function
1.31895	receptor activity	Fc receptor-like 1 [RefSeq_peptide;Acc:NP_443170]
1.33329	beta-mannosidase activity	Beta-mannosidase precursor (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase). [Uniprot/SWISSPROT;Acc:O00462]
	carbohydrate metabolic process		biological process
	cation binding		molecular function
	glycoprotein catabolic process		biological process
	hydrolase activity, hydrolyzing O-glycosyl compounds		molecular function
	lysosome		cellular component
	metabolic process		biological process
	protein modification process
1.33465	cell-cell signaling	T-box transcription factor TBX5 (T-box protein 5). [Uniprot/SWISSPROT;Acc:Q99593]
	cytoplasm		cellular component
	embryonic arm morphogenesis		biological process
	embryonic limb morphogenesis
	forelimb morphogenesis
	heart development
	induction of apoptosis
	lung development
	morphogenesis of an epithelium
	multicellular organismal development
	negative regulation of cardiac muscle cell proliferation
	negative regulation of cell migration
	nucleus		cellular component
	pattern specification process		biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.