MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1551 to 1600 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.76994	down	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]	biological process	cell adhesion
				myoblast fusion
				proteolysis
			cellular component	integral to membrane
				plasma membrane
			molecular function	metal ion binding
				metalloendopeptidase activity
				metallopeptidase activity
				protein binding
				zinc ion binding
1.78439	up	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]	biological process	chromatin assembly or disassembly
				chromatin modification
				chromosome organization and biogenesis (sensu Eukaryota)
				intracellular signaling cascade
				regulation of transcription from RNA polymerase II promoter
				transcription
			cellular component	chromatin
				nucleus
			molecular function	ATP binding
				ATP-dependent DNA helicase activity
				ATP-dependent helicase activity
				chromatin binding
				DNA binding
				helicase activity
				hydrolase activity
				metal ion binding
				nucleic acid binding
				nucleotide binding
				protein binding
				transcription factor binding
				zinc ion binding
1.78708		Centromere protein L (CENP-L) (Interphase centromere complex protein 33). [Uniprot/SWISSPROT;Acc:Q8N0S6]	cellular component	chromosome
				chromosome, pericentric region
				nucleus
1.79094		Protein FAM65A. [Uniprot/SWISSPROT;Acc:Q6ZS17]	biological process	signal transduction
			cellular component	intracellular
			molecular function	binding
1.7961		RAS-like, family 11, member A [RefSeq_peptide;Acc:NP_996563]	biological process	protein transport
				small GTPase mediated signal transduction
			cellular component	intracellular
			molecular function	GTP binding
				nucleotide binding
1.80858	down	Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]	biological process	signal transduction
			cellular component	intracellular
			molecular function	protein binding
				small GTPase regulator activity
1.80942		Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]	cellular component	integral to membrane
				membrane
1.81557		Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]	biological process	homoiothermy
				response to freezing

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.