MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Accession	Gene Ontology	Regulation	description	Class	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1551 to 1600 of 2667 in total

Ratio	Gene Ontology	Regulation	description	Class
1.76994	cell adhesion	down	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]	biological process
	integral to membrane			cellular component
	metal ion binding			molecular function
	metalloendopeptidase activity
	metallopeptidase activity
	myoblast fusion			biological process
	plasma membrane			cellular component
	protein binding			molecular function
	proteolysis			biological process
	zinc ion binding			molecular function
1.78439	ATP binding	up	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]
	ATP-dependent DNA helicase activity
	ATP-dependent helicase activity
	chromatin			cellular component
	chromatin assembly or disassembly			biological process
	chromatin binding			molecular function
	chromatin modification			biological process
	chromosome organization and biogenesis (sensu Eukaryota)
	DNA binding			molecular function
	helicase activity
	hydrolase activity
	intracellular signaling cascade			biological process
	metal ion binding			molecular function
	nucleic acid binding
	nucleotide binding
	nucleus			cellular component
	protein binding			molecular function
	regulation of transcription from RNA polymerase II promoter			biological process
	transcription
	transcription factor binding			molecular function
	zinc ion binding
1.78708	chromosome		Centromere protein L (CENP-L) (Interphase centromere complex protein 33). [Uniprot/SWISSPROT;Acc:Q8N0S6]	cellular component
	chromosome, pericentric region
	nucleus
1.79094	binding		Protein FAM65A. [Uniprot/SWISSPROT;Acc:Q6ZS17]	molecular function
	intracellular			cellular component
	signal transduction			biological process
1.7961	GTP binding		RAS-like, family 11, member A [RefSeq_peptide;Acc:NP_996563]	molecular function
	intracellular			cellular component
	nucleotide binding			molecular function
	protein transport			biological process
	small GTPase mediated signal transduction
1.80858	intracellular	down	Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]	cellular component
	protein binding			molecular function
	signal transduction			biological process
	small GTPase regulator activity			molecular function
1.80942	integral to membrane		Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]	cellular component
	membrane
1.81557	ATP binding		Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]	molecular function
	DNA binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.