MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1519 to 1568 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.73291	up	BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	molecular function	protein binding
				voltage-gated potassium channel activity
1.74736	down	Proline-serine-threonine phosphatase-interacting protein 2. [Uniprot/SWISSPROT;Acc:Q9H939]	cellular component	cytoplasm
				membrane
1.75026	up	Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]	biological process	axon ensheathment
				calcium-independent cell-cell adhesion
				cell adhesion
				spermatogenesis
			cellular component	cell junction
				integral to membrane
				membrane
				tight junction
			molecular function	identical protein binding
				structural molecule activity
1.75846	down	Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]	biological process	amino acid metabolic process
				L-cystine transport
				transport
			cellular component	integral to membrane
				lysosomal membrane
				lysosome
				membrane
			molecular function	L-cystine transporter activity
1.76583		leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]	biological process	antigen processing and presentation of endogenous peptide antigen via MHC class I
				blood pressure regulation
				proteolysis
			cellular component	endoplasmic reticulum lumen
			molecular function	aminopeptidase activity
				membrane alanyl aminopeptidase activity
				metallopeptidase activity
				N-terminal arginine aminopeptidase activity
				N-terminal lysine aminopeptidase activity
				zinc ion binding
1.76994		ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]	biological process	cell adhesion
				myoblast fusion
				proteolysis
			cellular component	integral to membrane
				plasma membrane
			molecular function	metal ion binding
				metalloendopeptidase activity
				metallopeptidase activity
				protein binding
				zinc ion binding
1.78439	up	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]	biological process	chromatin assembly or disassembly
				chromatin modification
				chromosome organization and biogenesis (sensu Eukaryota)
				intracellular signaling cascade
				regulation of transcription from RNA polymerase II promoter
				transcription
			cellular component	chromatin
				nucleus

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.