MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1518 to 1567 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.73291	up	BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	protein binding	molecular function
			voltage-gated potassium channel activity
			voltage-gated potassium channel complex	cellular component
1.74736	down	Proline-serine-threonine phosphatase-interacting protein 2. [Uniprot/SWISSPROT;Acc:Q9H939]	cytoplasm
			membrane
1.75026	up	Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]	axon ensheathment	biological process
			calcium-independent cell-cell adhesion
			cell adhesion
			cell junction	cellular component
			identical protein binding	molecular function
			integral to membrane	cellular component
			membrane
			spermatogenesis	biological process
			structural molecule activity	molecular function
			tight junction	cellular component
1.75846	down	Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]	amino acid metabolic process	biological process
			integral to membrane	cellular component
			L-cystine transport	biological process
			L-cystine transporter activity	molecular function
			lysosomal membrane	cellular component
			lysosome
			membrane
			transport	biological process
1.76583		leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]	aminopeptidase activity	molecular function
			antigen processing and presentation of endogenous peptide antigen via MHC class I	biological process
			blood pressure regulation
			endoplasmic reticulum lumen	cellular component
			membrane alanyl aminopeptidase activity	molecular function
			metallopeptidase activity
			N-terminal arginine aminopeptidase activity
			N-terminal lysine aminopeptidase activity
			proteolysis	biological process
			zinc ion binding	molecular function
1.76994		ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]	cell adhesion	biological process
			integral to membrane	cellular component
			metal ion binding	molecular function
			metalloendopeptidase activity
			metallopeptidase activity
			myoblast fusion	biological process
			plasma membrane	cellular component
			protein binding	molecular function
			proteolysis	biological process
			zinc ion binding	molecular function
1.78439	up	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]	ATP binding
			ATP-dependent DNA helicase activity
			ATP-dependent helicase activity
			chromatin	cellular component
			chromatin assembly or disassembly	biological process
			chromatin binding	molecular function
			chromatin modification	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.