MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 151 to 200 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.21384	Disco-interacting protein 2 homolog C. [Uniprot/SWISSPROT;Acc:Q9Y2E4]	biological process	metabolic process
		cellular component	nucleus
		molecular function	catalytic activity
			transcription factor binding
1.21871	Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1). [Uniprot/SWISSPROT;Acc:Q13323]	biological process	apoptotic program
			induction of apoptosis
			regulation of apoptosis
		cellular component	integral to membrane
			membrane
			mitochondrial envelope
		molecular function	protein binding
1.23668	Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160]	biological process	biological_process
		cellular component	myosin complex
			unconventional myosin complex
		molecular function	actin binding
			ATP binding
			calmodulin binding
			motor activity
			nucleoside-triphosphatase activity
			nucleotide binding
1.23783	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Uniprot/SWISSPROT;Acc:Q8WZ64]	biological process	regulation of GTPase activity
			signal transduction
		cellular component	cytoplasm
			intracellular
		molecular function	GTPase activator activity
			metal ion binding
			phosphatidylinositol-3,4,5-triphosphate binding
			zinc ion binding
1.23845	Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]	biological process	cell proliferation
			cholesterol metabolic process
			lipid metabolic process
			metabolic process
			response to sterol depletion
			steroid metabolic process
		cellular component	endoplasmic reticulum
			integral to membrane
			membrane
		molecular function	protein binding
1.24114	Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3]	biological process	signal transduction
			striated muscle contraction
		cellular component	intracellular
			myosin complex
			striated muscle thick filament
		molecular function	actin binding
			ATP binding
			calmodulin binding
			motor activity
			nucleotide binding
1.24359	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2). [Uniprot/SWISSPROT;Acc:Q86UW7]	biological process	exocytosis
			protein transport

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.