MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Accession	Regulation	Ratio	Gene Ontology	Minimum Ratio	description	Class	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 151 to 200 of 2667 in total

Regulation  : down

Ratio	Gene Ontology	description	Class
1.21384	catalytic activity	Disco-interacting protein 2 homolog C. [Uniprot/SWISSPROT;Acc:Q9Y2E4]	molecular function
	metabolic process		biological process
	nucleus		cellular component
	transcription factor binding		molecular function
1.21871	apoptotic program	Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1). [Uniprot/SWISSPROT;Acc:Q13323]	biological process
	induction of apoptosis
	integral to membrane		cellular component
	membrane
	mitochondrial envelope
	protein binding		molecular function
	regulation of apoptosis		biological process
1.23668	actin binding	Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160]	molecular function
	ATP binding
	biological_process		biological process
	calmodulin binding		molecular function
	motor activity
	myosin complex		cellular component
	nucleoside-triphosphatase activity		molecular function
	nucleotide binding
	unconventional myosin complex		cellular component
1.23783	cytoplasm	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Uniprot/SWISSPROT;Acc:Q8WZ64]
	GTPase activator activity		molecular function
	intracellular		cellular component
	metal ion binding		molecular function
	phosphatidylinositol-3,4,5-triphosphate binding
	regulation of GTPase activity		biological process
	signal transduction
	zinc ion binding		molecular function
1.23845	cell proliferation	Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]	biological process
	cholesterol metabolic process
	endoplasmic reticulum		cellular component
	integral to membrane
	lipid metabolic process		biological process
	membrane		cellular component
	metabolic process		biological process
	protein binding		molecular function
	response to sterol depletion		biological process
	steroid metabolic process
1.24114	actin binding	Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3]	molecular function
	ATP binding
	calmodulin binding
	intracellular		cellular component
	motor activity		molecular function
	myosin complex		cellular component
	nucleotide binding		molecular function
	signal transduction		biological process
	striated muscle contraction
	striated muscle thick filament		cellular component
1.24359	calcium ion binding	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2). [Uniprot/SWISSPROT;Acc:Q86UW7]	molecular function
	cell junction		cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.