MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1469 to 1518 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.693	down	CDK5 regulatory subunit associated protein 1-like 1 [RefSeq_peptide;Acc:NP_060244]	molecular function	iron-sulfur cluster binding
1.69345	up	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Uniprot/SWISSPROT;Acc:P16383]	biological process	regulation of transcription
				regulation of transcription, DNA-dependent
			cellular component	nucleus
			molecular function	DNA binding
				RNA polymerase II transcription factor activity
				transcription factor activity
1.69658	down	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). [Uniprot/SWISSPROT;Acc:Q11206]	biological process	protein amino acid glycosylation
			cellular component	Golgi apparatus
				integral to Golgi membrane
				integral to membrane
				membrane
			molecular function	beta-galactoside alpha-2,3-sialyltransferase activity
				sialyltransferase activity
				transferase activity, transferring glycosyl groups
1.69856	up	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Uniprot/SWISSPROT;Acc:Q9H1R3]	biological process	neuromuscular synaptic transmission
				protein amino acid phosphorylation
			cellular component	cytoplasm
			molecular function	ATP binding
				calmodulin binding
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
1.72628	down	Coiled-coil domain-containing protein 108. [Uniprot/SWISSPROT;Acc:Q6ZU64]	biological process	DNA repair
			cellular component	integral to membrane
				membrane
			molecular function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
				structural molecule activity
1.72656		protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]	biological process	ER overload response
				response to hydrogen peroxide
				response to oxidative stress
			cellular component	protein phosphatase type 1 complex
			molecular function	protein serine/threonine phosphatase activity
1.73211		Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]	biological process	cell cycle
				cell proliferation
				meiosis
				regulation of progression through cell cycle
			cellular component	chromosome, pericentric region
				condensed chromosome
				cytoplasm
				nucleolus
				nucleus
			molecular function	ATP binding
				nucleotide binding
				protein binding
1.73291	up	BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	biological process	potassium ion transport
			cellular component	membrane
				voltage-gated potassium channel complex

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.