MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Gene Ontology	Regulation	description	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1455 to 1504 of 2667 in total

Ratio	Gene Ontology	Regulation	description	Class
1.66679	transferase activity, transferring glycosyl groups	up	TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]	molecular function
	zinc ion binding
1.683	cytoplasm	down	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]	cellular component
	exonuclease activity			molecular function
	exosome (RNase complex)			cellular component
	GDP-dissociation stimulator activity			molecular function
	hydrolase activity
	nucleus			cellular component
	ribonuclease activity			molecular function
	RNA binding
	rRNA processing			biological process
1.69153	intermediate filament		Keratin-associated protein 19-2. [Uniprot/SWISSPROT;Acc:Q3LHN2]	cellular component
1.693	catalytic activity		CDK5 regulatory subunit associated protein 1-like 1 [RefSeq_peptide;Acc:NP_060244]	molecular function
	iron-sulfur cluster binding
	metabolic process			biological process
1.69345	DNA binding	up	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Uniprot/SWISSPROT;Acc:P16383]	molecular function
	nucleus			cellular component
	regulation of transcription			biological process
	regulation of transcription, DNA-dependent
	RNA polymerase II transcription factor activity			molecular function
	transcription factor activity
1.69658	beta-galactoside alpha-2,3-sialyltransferase activity	down	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). [Uniprot/SWISSPROT;Acc:Q11206]
	Golgi apparatus			cellular component
	integral to Golgi membrane
	integral to membrane
	membrane
	protein amino acid glycosylation			biological process
	sialyltransferase activity			molecular function
	transferase activity, transferring glycosyl groups
1.69856	ATP binding	up	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Uniprot/SWISSPROT;Acc:Q9H1R3]
	calmodulin binding
	cytoplasm			cellular component
	neuromuscular synaptic transmission			biological process
	nucleotide binding			molecular function
	protein amino acid phosphorylation			biological process
	protein kinase activity			molecular function
	protein serine/threonine kinase activity
	protein-tyrosine kinase activity
	transferase activity
1.72628	DNA repair	down	Coiled-coil domain-containing protein 108. [Uniprot/SWISSPROT;Acc:Q6ZU64]	biological process
	integral to membrane			cellular component
	membrane
	methylated-DNA-[protein]-cysteine S-methyltransferase activity			molecular function
	structural molecule activity
1.72656	ER overload response		protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]	biological process
	protein phosphatase type 1 complex			cellular component
	protein serine/threonine phosphatase activity			molecular function
	response to hydrogen peroxide			biological process
	response to oxidative stress
1.73211	ATP binding		Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.