MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1369 to 1418 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
1.19539	Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). [Uniprot/SWISSPROT;Acc:Q9Y697]	molecular function	transferase activity
1.19545	Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Uniprot/SWISSPROT;Acc:O00115]	biological process	apoptosis
			DNA catabolic process
			DNA metabolic process
			erythrocyte differentiation
			multicellular organismal development
		cellular component	extracellular region
			lysosome
		molecular function	deoxyribonuclease II activity
			DNA binding
			endodeoxyribonuclease activity
			endonuclease activity
			hormone activity
			hydrolase activity
			protein binding
1.20102	Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Uniprot/SWISSPROT;Acc:Q658P3]	biological process	apoptosis
			cell cycle
			electron transport
			ion transport
			iron ion transport
		cellular component	endosome
			integral to membrane
			membrane
			plasma membrane
		molecular function	copper ion binding
			FAD binding
			ferric-chelate reductase activity
			iron ion binding
			metal ion binding
			oxidoreductase activity
1.21657	Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]	biological process	cell cycle
			cytokinesis
			positive regulation of exocytosis
			regulation of exocytosis
			small GTPase mediated signal transduction
			synaptic vesicle targeting
		cellular component	plasma membrane
			synaptic vesicle
			synaptosome
		molecular function	GTP binding
			GTPase activity
			nucleotide binding
			protein binding
			structural molecule activity
			syntaxin binding
1.21698	Kelch-like protein 34. [Uniprot/SWISSPROT;Acc:Q8N239]	biological process	electron transport
			metabolic process
		molecular function	oxidoreductase activity
			protein binding
1.21705	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta). [Uniprot/SWISSPROT;Acc:P78371]	biological process	cellular protein metabolic process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.