MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

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Showing element 1368 to 1417 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
1.61987	Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]	biological process	cell motility
			elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
			establishment of synaptic specificity at neuromuscular junction
			G-protein coupled receptor protein signaling pathway
			multicellular organismal development
			negative regulation of neuron apoptosis
			positive regulation of calcium ion transport
			positive regulation of cell proliferation
			positive regulation of I-kappaB kinase/NF-kappaB cascade
			positive regulation of smooth muscle contraction
			positive regulation of vasoconstriction
			protein kinase C activation
			regulation of progression through cell cycle
			regulation of sensory perception of pain
			release of sequestered calcium ion into cytosol
			response to wounding
			signal transduction
			STAT protein nuclear translocation
			tyrosine phosphorylation of STAT protein
		cellular component	Golgi apparatus
			integral to membrane
			integral to plasma membrane
			neuromuscular junction
			plasma membrane
			postsynaptic membrane
		molecular function	G-protein coupled receptor activity
			purinergic nucleotide receptor activity, G-protein coupled
			receptor activity
			receptor binding
			rhodopsin-like receptor activity
			thrombin receptor activity
1.62157	EF-hand domain-containing family member B. [Uniprot/SWISSPROT;Acc:Q8N7U6]		calcium ion binding
1.62709	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14). [Uniprot/SWISSPROT;Acc:Q9H3S7]	biological process	dephosphorylation
			protein amino acid dephosphorylation
		cellular component	cytoplasmic vesicle
		molecular function	hydrolase activity
			phosphoric monoester hydrolase activity
			protein tyrosine phosphatase activity
1.63639	Cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia). [Uniprot/SWISSPROT;Acc:Q9UKJ5]	biological process	biological_process
		cellular component	cellular_component
			cytoplasmic vesicle
			Golgi apparatus
			Golgi-associated vesicle
			plasma membrane
		molecular function	molecular_function
1.63713	Armadillo repeat-containing X-linked protein 3 (Protein ALEX3) (ARM protein lost in epithelial cancers on chromosome X 3). [Uniprot/SWISSPROT;Acc:Q9UH62]	cellular component	integral to membrane
			membrane
		molecular function	binding
1.6384	Olfactory receptor 6S1. [Uniprot/SWISSPROT;Acc:Q8NH40]	biological process	G-protein coupled receptor protein signaling pathway
			signal transduction

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.