MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1355 to 1404 of 2667 in total

Regulation  : up

Ratio	description	Gene Ontology	Class
1.61673	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase). [Uniprot/SWISSPROT;Acc:Q6P2M8]	cytoplasm	cellular component
		nucleotide binding	molecular function
		nucleus	cellular component
		protein amino acid phosphorylation	biological process
		protein kinase activity	molecular function
		protein serine/threonine kinase activity
		protein-tyrosine kinase activity
		transferase activity
1.61987	Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]	activation of MAPKK activity	biological process
		anatomical structure morphogenesis
		apoptosis
		blood coagulation
		caspase activation
		cell motility
		elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
		establishment of synaptic specificity at neuromuscular junction
		G-protein coupled receptor activity	molecular function
		G-protein coupled receptor protein signaling pathway	biological process
		Golgi apparatus	cellular component
		integral to membrane
		integral to plasma membrane
		multicellular organismal development	biological process
		negative regulation of neuron apoptosis
		neuromuscular junction	cellular component
		plasma membrane
		positive regulation of calcium ion transport	biological process
		positive regulation of cell proliferation
		positive regulation of I-kappaB kinase/NF-kappaB cascade
		positive regulation of smooth muscle contraction
		positive regulation of vasoconstriction
		postsynaptic membrane	cellular component
		protein kinase C activation	biological process
		purinergic nucleotide receptor activity, G-protein coupled	molecular function
		receptor activity
		receptor binding
		regulation of progression through cell cycle	biological process
		regulation of sensory perception of pain
		release of sequestered calcium ion into cytosol
		response to wounding
		rhodopsin-like receptor activity	molecular function
		signal transduction	biological process
		STAT protein nuclear translocation
		thrombin receptor activity	molecular function
		tyrosine phosphorylation of STAT protein	biological process
1.62157	EF-hand domain-containing family member B. [Uniprot/SWISSPROT;Acc:Q8N7U6]	calcium ion binding	molecular function
1.62709	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14). [Uniprot/SWISSPROT;Acc:Q9H3S7]	cytoplasmic vesicle	cellular component
		dephosphorylation	biological process
		hydrolase activity	molecular function
		phosphoric monoester hydrolase activity
		protein amino acid dephosphorylation	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.