MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1219 to 1268 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.50284	down	AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Uniprot/SWISSPROT;Acc:P59780]	molecular function	protein binding
				protein transporter activity
1.50715		F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5). [Uniprot/SWISSPROT;Acc:Q969U6]	biological process	ubiquitin cycle
			molecular function	protein binding
1.51342		Beta-defensin 2 precursor (BD-2) (hBD-2) (Defensin, beta 2) (Skin- antimicrobial peptide 1) (SAP1). [Uniprot/SWISSPROT;Acc:O15263]	biological process	chemotaxis
				defense response
				defense response to bacterium
				G-protein coupled receptor protein signaling pathway
				immune response
			cellular component	extracellular region
1.5415		Pleckstrin homology-like domain family B member 2 (Protein LL5-beta). [Uniprot/SWISSPROT;Acc:Q86SQ0]	biological process	chloride transport
				intracellular signaling cascade
				signal transduction
			cellular component	cytoplasm
				membrane
			molecular function	phospholipase C activity
				voltage-gated chloride channel activity
1.54317	up	Dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117) (DolP- glucosyltransferase). [Uniprot/SWISSPROT;Acc:Q9Y673]	biological process	determination of left/right symmetry
				protein amino acid glycosylation
			cellular component	endoplasmic reticulum
				integral to membrane
				membrane
			molecular function	dolichyl-phosphate beta-glucosyltransferase activity
				oligosaccharyl transferase activity
				transferase activity, transferring glycosyl groups
1.54676	down	WAS protein homology region 2 domain containing 1 [RefSeq_peptide;Acc:NP_001073904]	biological process	cell adhesion
			cellular component	actin cytoskeleton
				extracellular region
			molecular function	actin binding
				hormone activity
				structural molecule activity
1.55809		Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class H protein) (PIG-H). [Uniprot/SWISSPROT;Acc:Q14442]	biological process	GPI anchor biosynthetic process
				protein modification process
			cellular component	cytoplasm
				endoplasmic reticulum
			molecular function	phosphatidylinositol N-acetylglucosaminyltransferase activity
				transferase activity, transferring glycosyl groups
1.55844	up	TP53-target gene 5 protein (TP53-inducible gene 5 protein). [Uniprot/SWISSPROT;Acc:Q9Y2B4]	biological process	intracellular signaling cascade
				negative regulation of cell growth
			molecular function	molecular_function
1.56335		Zinc finger SWIM domain-containing protein 3. [Uniprot/SWISSPROT;Acc:Q96MP5]		metal ion binding
				zinc ion binding
1.57088		Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein). [Uniprot/SWISSPROT;Acc:O15409]	biological process	caudate nucleus development
				putamen development
				regulation of transcription, DNA-dependent
				transcription
			cellular component	intracellular
				nucleus
			molecular function	metal ion binding
				nucleic acid binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.