MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 118 to 167 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.15279	up	Podocalyxin-like protein 2 precursor (Endoglycan). [Uniprot/SWISSPROT;Acc:Q9NZ53]	cellular component	membrane
				viral capsid
			molecular function	glycosaminoglycan binding
				protein binding
				structural molecule activity
1.1611	down	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	biological process	electron transport
				signal transduction
			cellular component	extracellular region
			molecular function	electron carrier activity
				enzyme activator activity
				guanylate cyclase activator activity
				hormone activity
1.16158	up	transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 [RefSeq_dna;Acc:NR_002720]	biological process	calcium ion transport
				ion transport
			cellular component	membrane
			molecular function	calcium channel activity
				ion channel activity
1.16173		oligonucleotide/oligosaccharide-binding fold containing 2B [RefSeq_peptide;Acc:NP_076973]		nucleic acid binding
1.16363		Sperm acrosome membrane-associated protein 1 precursor (Sperm acrosomal membrane-associated protein 32). [Uniprot/SWISSPROT;Acc:Q9HBV2]	cellular component	integral to membrane
				membrane
1.16393		olfactory receptor, family 5, subfamily K, member 4 [RefSeq_peptide;Acc:NP_001005517]	biological process	G-protein coupled receptor protein signaling pathway
			cellular component	integral to membrane
			molecular function	olfactory receptor activity
				rhodopsin-like receptor activity
1.16499		ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	biological process	cell adhesion
				central nervous system development
				negative regulation of cell adhesion
				proteolysis
			cellular component	integral to membrane
				membrane
			molecular function	integrin binding
				metalloendopeptidase activity
				protein binding
				zinc ion binding
1.16823		S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1). [Uniprot/SWISSPROT;Acc:Q13309]	biological process	cell proliferation
				G1/S transition of mitotic cell cycle
				regulation of progression through cell cycle
				ubiquitin cycle
			molecular function	protein binding
1.16921		Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]	biological process	cell differentiation
				multicellular organismal development
				nervous system development
				regulation of transcription
				regulation of transcription from RNA polymerase II promoter
				regulation of transcription, DNA-dependent
			cellular component	nucleus
				transcription factor complex
			molecular function	DNA binding
				transcription cofactor activity
				transcription factor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.