MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1118 to 1167 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.48363	down	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). [Uniprot/SWISSPROT;Acc:P30291]	cell division	biological process
			magnesium ion binding	molecular function
			mitosis	biological process
			nucleotide binding	molecular function
			nucleus	cellular component
			protein amino acid phosphorylation	biological process
			protein binding	molecular function
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			regulation of progression through cell cycle	biological process
			transferase activity	molecular function
1.48389		Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin). [Uniprot/SWISSPROT;Acc:P49790]	ATP binding
			ATP synthesis coupled proton transport	biological process
			DNA binding	molecular function
			hydrogen ion transporting ATP synthase activity, rotational mechanism
			hydrogen ion transporting ATPase activity, rotational mechanism
			intracellular	cellular component
			intracellular protein transport across a membrane	biological process
			metal ion binding	molecular function
			mRNA transport	biological process
			nuclear pore	cellular component
			nucleus
			protein binding	molecular function
			protein transport	biological process
			proton-transporting two-sector ATPase complex	cellular component
			transporter activity	molecular function
			zinc ion binding
1.49264	up	Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1). [Uniprot/SWISSPROT;Acc:Q8TAV3]	electron transport	biological process
			endoplasmic reticulum	cellular component
			heme binding	molecular function
			iron ion binding
			membrane	cellular component
			metal ion binding	molecular function
			monooxygenase activity
			oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
1.49271	down	Cullin-4B (CUL-4B). [Uniprot/SWISSPROT;Acc:Q13620]	cell cycle	biological process
			cellular_component	cellular component
			DNA repair	biological process
			molecular_function	molecular function
			protein binding
			ubiquitin cycle	biological process
1.49444	up	Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin-protein ligase R2) (Ubiquitin carrier protein R2) (E2-CDC34B). [Uniprot/SWISSPROT;Acc:Q712K3]	ligase activity	molecular function
			protein modification process	biological process
			small conjugating protein ligase activity	molecular function
			ubiquitin cycle	biological process
			ubiquitin-protein ligase activity	molecular function
1.49558	down	Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643]	BMP signaling pathway	biological process
			bone mineralization
			cardiac cell differentiation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.