MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Accession	Gene Ontology	description	Gene	Minimum Ratio	Class	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1101 to 1150 of 2667 in total

Regulation  : down

Ratio	Gene Ontology	description	Class
5.23046	phosphoinositide-mediated signaling	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736]	biological process
	phosphotransferase activity, alcohol group as acceptor		molecular function
	protein amino acid phosphorylation		biological process
	protein binding		molecular function
	transferase activity
5.32612	cellular respiration	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Uniprot/SWISSPROT;Acc:Q12968]	biological process
	cytoplasm		cellular component
	heart development		biological process
	inflammatory response
	nucleus		cellular component
	protein binding		molecular function
	regulation of transcription		biological process
	regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	transcription coactivator activity		molecular function
	transcription factor activity
5.61927	integral to membrane	RING finger protein 170 (Putative LAG1-interacting protein). [Uniprot/SWISSPROT;Acc:Q96K19]	cellular component
	membrane
	metal ion binding		molecular function
	nucleoside transporter activity
	protein binding
	transport		biological process
	zinc ion binding		molecular function
5.83544	chromatin remodeling	Nucleoplasmin-2. [Uniprot/SWISSPROT;Acc:Q86SE8]	biological process
	cytoplasmic chromatin		cellular component
	embryonic development		biological process
	histone binding		molecular function
	nuclear chromatin		cellular component
	nucleic acid binding		molecular function
	nucleus		cellular component
	oocyte differentiation		biological process
	positive regulation of meiosis
	regulation of exit from mitosis
	single fertilization
5.84607	axonogenesis	Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813]
	beta-tubulin folding
	chaperone binding		molecular function
	cytoplasm		cellular component
	cytoskeleton
	microtubule
	microtubule cytoskeleton organization and biogenesis		biological process
	protein binding		molecular function
	protein folding		biological process
	protein modification process
6.3909	apoptosis	Protein Jade-1 (PHD finger protein 17). [Uniprot/SWISSPROT;Acc:Q6IE81]
	cytoplasm		cellular component
	intracellular signaling cascade		biological process
	metal ion binding		molecular function
	negative regulation of cell growth		biological process
	nucleus		cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.