Scientific
MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis
These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.
Affected Genes

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Ratio Regulation description Gene Ontology Class Gene Accession Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX
Showing element 1051 to 1100 of 2667 in total

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\begin{longtable}{|c|c|c|c|c|}
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
Ratio\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
Regulation\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
description\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
Gene Ontology\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
Class\vspace{3pt}}\\
\hline
\hline
\multirow{4}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.43351\vspace{3pt}}}&\multirow{8}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\multirow{4}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Carboxypeptidase A2 precursor (EC 3.4.17.15). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
metallopeptidase activity\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
proteolysis\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
vacuolar protein catabolic process\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
zinc ion binding\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{1-1}\cline{3-5}
\multirow{4}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.44004\vspace{3pt}}}&&\multirow{4}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Cytokine-like protein 1 precursor (Protein C17). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
extracellular space\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
receptor binding\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
signal transduction\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
soluble fraction\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}\\\hline
\multirow{8}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.44789\vspace{3pt}}}&\multirow{42}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\multirow{8}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
DNA binding\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
humoral immune response\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleus\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
protein binding\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of transcription, DNA-dependent\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transcription\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transcription coactivator activity\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transcription from RNA polymerase II promoter\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}\\\cline{1-1}\cline{3-5}
\multirow{12}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.45148\vspace{3pt}}}&&\multirow{12}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
DNA binding\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
ER-Golgi intermediate compartment\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
Golgi apparatus\vspace{3pt}}&\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
Golgi membrane\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
Golgi organization and biogenesis\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
Golgi stack\vspace{3pt}}&\multirow{4}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}&\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}&\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleus\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
protein binding\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of transcription, DNA-dependent\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
vesicle-mediated transport\vspace{3pt}}&\\\cline{1-1}\cline{3-5}
\parbox{\wcA}{\vspace{3pt}\noindent
1.45314\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
NULL\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
DNA binding\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{1-1}\cline{3-5}
\multirow{12}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.45624\vspace{3pt}}}&&\multirow{12}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
circulation\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
DNA binding\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
hemostasis\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
multicellular organismal development\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleus\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
protein dimerization activity\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of transcription\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of transcription from RNA polymerase II promoter\vspace{3pt}}&\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of transcription, DNA-dependent\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
sequence-specific DNA binding\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transcription coactivator activity\vspace{3pt}}&\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transcription factor activity\vspace{3pt}}&\\\cline{1-1}\cline{3-5}
\multirow{9}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.45635\vspace{3pt}}}&&\multirow{9}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Cyclin-A2 (Cyclin-A). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
cell cycle\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cell division\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cytoplasm\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
female pronucleus\vspace{3pt}}&\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
male pronucleus\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
mitosis\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
mitotic G2 checkpoint\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleus\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
positive regulation of transcription\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}\\\hline
nd{longtable}

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.

 - The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 

 - The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 

 - The Gene Ontology terms as linked to the specific gene.

 - Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray

 - Accession is the GO accession key. 

 - Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

 - Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/