MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1019 to 1068 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
3.83977	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Uniprot/SWISSPROT;Acc:Q8WYP5]	transcription factor activity	molecular function
3.99682	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein). [Uniprot/SWISSPROT;Acc:Q9P232]	ATP binding
		cell adhesion	biological process
		GPI anchor binding	molecular function
		interleukin-1 receptor activity
		membrane	cellular component
		protein amino acid phosphorylation	biological process
		protein binding	molecular function
		vascular endothelial growth factor receptor activity
4.14557	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]	ATP binding
		nucleotide binding
		nucleus	cellular component
		protein amino acid phosphorylation	biological process
		protein kinase activity	molecular function
		protein serine/threonine kinase activity
		transferase activity
4.21401	Uncharacterized protein C17orf56. [Uniprot/SWISSPROT;Acc:Q96N21]	membrane	cellular component
4.40797	Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]	alcohol metabolic process	biological process
		aldehyde dehydrogenase (NAD) activity	molecular function
		aldehyde dehydrogenase [NAD(P)+] activity
		carbohydrate metabolic process	biological process
		electron carrier activity	molecular function
		metabolic process	biological process
		mitochondrion	cellular component
		neuropeptide hormone activity	molecular function
		neuropeptide signaling pathway	biological process
		oxidoreductase activity	molecular function
4.4149	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]	DNA binding
		immune response	biological process
		nucleus	cellular component
		protein dimerization activity	molecular function
		regulation of transcription	biological process
		regulation of transcription, DNA-dependent
		sequence-specific DNA binding	molecular function
		transcription	biological process
		transcription factor activity	molecular function
4.49282	Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]	chromatin modification	biological process
		negative regulation of gene expression, epigenetic
		negative regulation of transcription from RNA polymerase II promoter
		nuclear membrane	cellular component
		nucleoplasm
		nucleus
		positive regulation of transcription from RNA polymerase II promoter	biological process
		regulation of cell growth
		regulation of transcription, DNA-dependent
		transcription
		transcriptional activator activity	molecular function
		transcriptional repressor activity
4.49844	Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide]. [Uniprot/SWISSPROT;Acc:P05060]	extracellular space	cellular component
		hormone activity	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.