MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	description	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1001 to 1050 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
1.40749	up	G-protein coupled receptor protein signaling pathway	collagen, type XXVII, alpha 1 [RefSeq_peptide;Acc:NP_116277]	biological process
		integral to membrane		cellular component
		phosphate transport		biological process
		structural constituent of cell wall		molecular function
		structural molecule activity
1.41851	down	insulin receptor binding	Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5). [Uniprot/SWISSPROT;Acc:Q9P104]
		MAPKKK cascade		biological process
		nervous system development
		transmembrane receptor protein tyrosine kinase signaling pathway
		transmembrane receptor protein tyrosine kinase signaling protein activity		molecular function
1.42215		integral to plasma membrane	Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Uniprot/SWISSPROT;Acc:P31645]	cellular component
		membrane
		monoamine transport		biological process
		monoamine transporter activity		molecular function
		neurotransmitter transport		biological process
		neurotransmitter uptake
		neurotransmitter:sodium symporter activity		molecular function
		protein binding
		serotonin transport		biological process
		serotonin transporter activity		molecular function
		serotonin:sodium symporter activity
		symporter activity
1.42264	up	cytoplasm	RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (hLark). [Uniprot/SWISSPROT;Acc:Q9BWF3]	cellular component
		homoiothermy		biological process
		ice binding		molecular function
		intracellular		cellular component
		metal ion binding		molecular function
		mRNA processing		biological process
		nucleic acid binding		molecular function
		nucleotide binding
		nucleus		cellular component
		response to freezing		biological process
		ribosome		cellular component
		RNA binding		molecular function
		RNA splicing		biological process
		structural constituent of ribosome		molecular function
		translation		biological process
		type I hypersensitivity
		zinc ion binding		molecular function
1.43088	down	carotenoid biosynthetic process	Isopentenyl-diphosphate Delta-isomerase 2 (EC 5.3.3.2) (IPP isomerase 2) (Isopentenyl pyrophosphate isomerase 2) (IPPI2). [Uniprot/SWISSPROT;Acc:Q9BXS1]	biological process
		cholesterol biosynthetic process
		hydrolase activity		molecular function
		isomerase activity
		isopentenyl-diphosphate delta-isomerase activity
		isoprenoid biosynthetic process		biological process
		magnesium ion binding		molecular function
		peroxisome		cellular component
1.43351		carboxypeptidase A activity	Carboxypeptidase A2 precursor (EC 3.4.17.15). [Uniprot/SWISSPROT;Acc:P48052]	molecular function
		carboxypeptidase activity
		metal ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.