MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Accession	Ratio	Regulation	Gene Ontology	Minimum Ratio	description	Gene	Class	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 101 to 150 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
1.14311	down	insulin-like growth factor receptor binding	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	molecular function
		negative regulation of protein kinase activity		biological process
		protein domain specific binding		molecular function
		protein kinase C binding
		protein kinase C inhibitor activity
		protein targeting		biological process
		regulation of neuron differentiation
		regulation of signal transduction
		regulation of synaptic plasticity
1.14915	up	cell-cell signaling	Transmembrane emp24 domain-containing protein 1 precursor (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor- binding protein). [Uniprot/SWISSPROT;Acc:Q13445]
		integral to membrane		cellular component
		membrane
		receptor binding		molecular function
		signal transduction		biological process
		transport
1.15279		cell adhesion	Podocalyxin-like protein 2 precursor (Endoglycan). [Uniprot/SWISSPROT;Acc:Q9NZ53]
		glycosaminoglycan binding		molecular function
		integral to plasma membrane		cellular component
		membrane
		protein binding		molecular function
		structural molecule activity
		viral capsid		cellular component
1.1611	down	electron carrier activity	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	molecular function
		electron transport		biological process
		enzyme activator activity		molecular function
		extracellular region		cellular component
		guanylate cyclase activator activity		molecular function
		hormone activity
		signal transduction		biological process
1.16158	up	calcium channel activity	transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 [RefSeq_dna;Acc:NR_002720]	molecular function
		calcium ion transport		biological process
		ion channel activity		molecular function
		ion transport		biological process
		membrane		cellular component
1.16173		nucleic acid binding	oligonucleotide/oligosaccharide-binding fold containing 2B [RefSeq_peptide;Acc:NP_076973]	molecular function
1.16363		integral to membrane	Sperm acrosome membrane-associated protein 1 precursor (Sperm acrosomal membrane-associated protein 32). [Uniprot/SWISSPROT;Acc:Q9HBV2]	cellular component
		membrane
1.16393		G-protein coupled receptor protein signaling pathway	olfactory receptor, family 5, subfamily K, member 4 [RefSeq_peptide;Acc:NP_001005517]	biological process
		integral to membrane		cellular component
		olfactory receptor activity		molecular function
		rhodopsin-like receptor activity
1.16499		cell adhesion	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	biological process
		central nervous system development
		integral to membrane		cellular component
		integrin binding		molecular function
		membrane		cellular component
		metalloendopeptidase activity		molecular function
		negative regulation of cell adhesion		biological process
		protein binding		molecular function
		proteolysis		biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.