MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Accession	Gene Ontology	description	Regulation	Class	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 101 to 150 of 2667 in total

Ratio	Gene Ontology	description	Regulation	Class
1.14311	insulin-like growth factor receptor binding	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	down	molecular function
	negative regulation of protein kinase activity			biological process
	protein domain specific binding			molecular function
	protein kinase C binding
	protein kinase C inhibitor activity
	protein targeting			biological process
	regulation of neuron differentiation
	regulation of signal transduction
	regulation of synaptic plasticity
1.14915	cell-cell signaling	Transmembrane emp24 domain-containing protein 1 precursor (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor- binding protein). [Uniprot/SWISSPROT;Acc:Q13445]	up
	integral to membrane			cellular component
	membrane
	receptor binding			molecular function
	signal transduction			biological process
	transport
1.15279	cell adhesion	Podocalyxin-like protein 2 precursor (Endoglycan). [Uniprot/SWISSPROT;Acc:Q9NZ53]
	glycosaminoglycan binding			molecular function
	integral to plasma membrane			cellular component
	membrane
	protein binding			molecular function
	structural molecule activity
	viral capsid			cellular component
1.1611	electron carrier activity	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	down	molecular function
	electron transport			biological process
	enzyme activator activity			molecular function
	extracellular region			cellular component
	guanylate cyclase activator activity			molecular function
	hormone activity
	signal transduction			biological process
1.16158	calcium channel activity	transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 [RefSeq_dna;Acc:NR_002720]	up	molecular function
	calcium ion transport			biological process
	ion channel activity			molecular function
	ion transport			biological process
	membrane			cellular component
1.16173	nucleic acid binding	oligonucleotide/oligosaccharide-binding fold containing 2B [RefSeq_peptide;Acc:NP_076973]		molecular function
1.16363	integral to membrane	Sperm acrosome membrane-associated protein 1 precursor (Sperm acrosomal membrane-associated protein 32). [Uniprot/SWISSPROT;Acc:Q9HBV2]		cellular component
	membrane
1.16393	G-protein coupled receptor protein signaling pathway	olfactory receptor, family 5, subfamily K, member 4 [RefSeq_peptide;Acc:NP_001005517]		biological process
	integral to membrane			cellular component
	olfactory receptor activity			molecular function
	rhodopsin-like receptor activity
1.16499	cell adhesion	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]		biological process
	central nervous system development
	integral to membrane			cellular component
	integrin binding			molecular function
	membrane			cellular component
	metalloendopeptidase activity			molecular function
	negative regulation of cell adhesion			biological process
	protein binding			molecular function
	proteolysis			biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.