Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Ontology Regulation Accession description Minimum Ratio Ratio Class Gene Maximum Ratio
Results: HTML CSV LaTeX Showing element 101 to 150 of 2667 in total
Gene Ontology
Regulation
description
Ratio
Class
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism down Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733] 1.20619 molecular function
up CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4). [Uniprot/SWISSPROT;Acc:Q8IZR5] 1.86433
ATPase activity, coupled to transmembrane movement of substances down Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D). [Uniprot/SWISSPROT;Acc:O15438] 1.30802
up ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Uniprot/SWISSPROT;Acc:Q99758] 1.22502
autophagic vacuole down Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) (Early estrogen-regulated protein). [Uniprot/SWISSPROT;Acc:Q9H0R8] 1.33817 cellular component
autophagic vacuole formation biological process
autophagy up Autophagy-related protein 10 (APG10-like). [Uniprot/SWISSPROT;Acc:Q9H0Y0] 1.28319
axon ensheathment Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508] 1.75026
axon guidance Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2) (Tyrosine-protein kinase TYRO6). [Uniprot/SWISSPROT;Acc:P54753] 3.48558
axon guidance receptor activity molecular function
axonogenesis down Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813] 5.84607 biological process
up Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H). [Uniprot/SWISSPROT;Acc:O15522] 1.30407
B cell differentiation CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965] 1.98149
B cell proliferation
basal plasma membrane down Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96] 1.30207 cellular component
base-excision repair up N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. [Uniprot/SWISSPROT;Acc:O15527] 1.35022 biological process
behavior down Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7] 3.27919
beta-galactoside alpha-2,3-sialyltransferase activity CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). [Uniprot/SWISSPROT;Acc:Q11206] 1.69658 molecular function
beta-mannosidase activity up Beta-mannosidase precursor (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase). [Uniprot/SWISSPROT;Acc:O00462] 1.33329
beta-tubulin binding down Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) (Early estrogen-regulated protein). [Uniprot/SWISSPROT;Acc:Q9H0R8] 1.33817
beta-tubulin folding Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813] 5.84607 biological process
binding Epididymal-specific lipocalin-12 precursor. [Uniprot/SWISSPROT;Acc:Q6JVE5] 2.51088 molecular function
up Armadillo repeat-containing X-linked protein 3 (Protein ALEX3) (ARM protein lost in epithelial cancers on chromosome X 3). [Uniprot/SWISSPROT;Acc:Q9UH62] 1.63713
CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (hOrbit2). [Uniprot/SWISSPROT;Acc:O75122] 1.29151
Protein FAM65A. [Uniprot/SWISSPROT;Acc:Q6ZS17] 1.79094
Suppressor of G2 allele of SKP1 homolog (Sgt1) (Putative 40-6-3 protein). [Uniprot/SWISSPROT;Acc:Q9Y2Z0] 3.03423
Tetratricopeptide repeat protein 18 (TPR repeat protein 18). [Uniprot/SWISSPROT;Acc:Q5T0N1] 1.58115
biological_process down Junctophilin-1 (Junctophilin type 1) (JP-1). [Uniprot/SWISSPROT;Acc:Q9HDC5] 3.39764 biological process
Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160] 1.23668
Neurosecretory protein VGF precursor. [Uniprot/SWISSPROT;Acc:O15240] 1.20481
Nucleolar preribosomal-associated protein 1 (Fragment). [Uniprot/SWISSPROT;Acc:O60287] 1.36755
Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29). [Uniprot/SWISSPROT;Acc:O95926] 3.43019
up Cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia). [Uniprot/SWISSPROT;Acc:Q9UKJ5] 1.63639
Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Uniprot/SWISSPROT;Acc:Q9H4M7] 1.17693
blood coagulation down Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435] 1.13541
up Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116] 1.61987
blood pressure regulation down leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745] 1.76583
Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354] 1.18096
blood vessel development Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905] 1.49923
up Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1] 1.25808
BMP signaling pathway down Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643] 1.49558
bombesin receptor activity Orexigenic neuropeptide QRFP receptor (G-protein coupled receptor 103) (SP9155) (AQ27). [Uniprot/SWISSPROT;Acc:Q96P65] 1.36911 molecular function
bone mineralization Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643] 1.49558 biological process
brain development up T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Uniprot/SWISSPROT;Acc:Q16650] 2.86298
brush border membrane Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879] 1.31661 cellular component
Cajal body Opa-interacting protein 5. [Uniprot/SWISSPROT;Acc:O43482] 2.72371
calcium channel activity Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0] 1.60668 molecular function
transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 [RefSeq_dna;Acc:NR_002720] 1.16158
transient receptor potential cation channel, subfamily M, member 1 [RefSeq_peptide;Acc:NP_002411] 2.8521
calcium channel regulator activity down Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879] 3.54799

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/