MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 551 to 600 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.25147	up	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Uniprot/SWISSPROT;Acc:P42081]	biological process	T cell activation
				T cell proliferation
			cellular component	external side of plasma membrane
				integral to membrane
				plasma membrane
			molecular function	coreceptor activity
				protein binding
				transcriptional activator activity
1.25205	down	Protein CWC15 homolog. [Uniprot/SWISSPROT;Acc:Q9P013]	biological process	nuclear mRNA splicing, via spliceosome
				RNA splicing
				SRP-dependent cotranslational protein targeting to membrane
			cellular component	membrane
				nucleus
				spliceosome
			molecular function	7S RNA binding
				GTP binding
				RNA binding
1.25729	up	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Uniprot/SWISSPROT;Acc:Q96LJ7]	biological process	enterobactin biosynthetic process
				metabolic process
			cellular component	endoplasmic reticulum
				mitochondrial inner membrane
			molecular function	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
				oxidoreductase activity
1.25808		Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process	adult heart development
				adult walking behavior
				blood vessel development
				camera-type eye development
				chromatin assembly or disassembly
				chromatin modification
				circulation
				embryonic hindlimb morphogenesis
				female genitalia development
				heart morphogenesis
				in utero embryonic development
				inner ear morphogenesis
				locomotory behavior
				nose development
				palate development
				positive regulation of body size
				regulation of transcription, DNA-dependent
				sensory perception of sound
				transcription
			cellular component	chromatin
				nucleus
			molecular function	ATP binding
				chromatin binding
				DNA binding
				helicase activity
				hydrolase activity
				nucleic acid binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.