MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2455 to 2504 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
4.4149	down	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]	biological process	regulation of transcription
				regulation of transcription, DNA-dependent
				transcription
			cellular component	nucleus
			molecular function	DNA binding
				protein dimerization activity
				sequence-specific DNA binding
				transcription factor activity
4.49282		Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]	biological process	chromatin modification
				negative regulation of gene expression, epigenetic
				negative regulation of transcription from RNA polymerase II promoter
				positive regulation of transcription from RNA polymerase II promoter
				regulation of cell growth
				regulation of transcription, DNA-dependent
				transcription
			cellular component	nuclear membrane
				nucleoplasm
				nucleus
			molecular function	transcriptional activator activity
				transcriptional repressor activity
4.49844		Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide]. [Uniprot/SWISSPROT;Acc:P05060]	cellular component	extracellular space
			molecular function	hormone activity
4.50619		Engulfment and cell motility protein 2 (CED-12 homolog A) (hCED-12A). [Uniprot/SWISSPROT;Acc:Q96JJ3]	biological process	apoptosis
				phagocytosis
			cellular component	cytoplasm
				cytoskeleton
				membrane
4.55177	up	Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]	biological process	establishment and/or maintenance of chromatin architecture
				nervous system development
				regulation of transcription, DNA-dependent
				transcription
			cellular component	chromatin
				nucleus
			molecular function	DNA binding
				transcription factor activity
4.55371		Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]	biological process	G-protein signaling, coupled to cyclic nucleotide second messenger
				signal transduction
				skeletal development
			cellular component	cytoplasm
				integral to membrane
				integral to plasma membrane
				membrane
				nucleus
			molecular function	G-protein coupled receptor activity
				parathyroid hormone receptor activity
				receptor activity
4.62042	down	Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26). [Uniprot/SWISSPROT;Acc:P11049]	biological process	protein amino acid N-linked glycosylation
				visual perception
			cellular component	integral to membrane
				integral to plasma membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.