Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes


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Gene Ontology Accession Minimum Ratio Ratio Regulation description Class Gene Maximum Ratio
Results: HTML CSV LaTeX Showing element 1 to 50 of 2667 in total
Gene Ontology
Ratio
Regulation
description
Class
1-phosphatidylinositol-3-kinase activity 5.23046 down Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736] molecular function
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity 1.25729 up Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Uniprot/SWISSPROT;Acc:Q96LJ7]
2-acylglycerol O-acyltransferase activity 3.31364 Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Diglyceride acyltransferase 2). [Uniprot/SWISSPROT;Acc:Q96PD7]
3-chloroallyl aldehyde dehydrogenase activity 1.20924 down Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895]
7S RNA binding 1.25205 Protein CWC15 homolog. [Uniprot/SWISSPROT;Acc:Q9P013]
acetyltransferase activity 3.00923 Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N- acetyltransferase type 1) (NAT-1). [Uniprot/SWISSPROT;Acc:P18440]
4.69231 Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (Polymorphic arylamine N-acetyltransferase) (PNAT) (N- acetyltransferase type 2) (NAT-2). [Uniprot/SWISSPROT;Acc:P11245]
actin binding 1.23668 Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160]
1.24114 Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3]
1.54676 WAS protein homology region 2 domain containing 1 [RefSeq_peptide;Acc:NP_001073904]
1.59177 up Transgelin-2 (SM22-alpha homolog). [Uniprot/SWISSPROT;Acc:P37802]
actin cytoskeleton 1.54676 down WAS protein homology region 2 domain containing 1 [RefSeq_peptide;Acc:NP_001073904] cellular component
activation of MAPKK activity 1.61987 up Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116] biological process
actomyosin structure organization and biogenesis 1.59177 Transgelin-2 (SM22-alpha homolog). [Uniprot/SWISSPROT;Acc:P37802]
acyltransferase activity 3.31364 Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Diglyceride acyltransferase 2). [Uniprot/SWISSPROT;Acc:Q96PD7] molecular function
adenohypophysis development 1.10867 Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Uniprot/SWISSPROT;Acc:P01286] biological process
adult heart development 1.25808 Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]
adult walking behavior
alcohol metabolic process 1.20924 down Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895]
4.40797 Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]
aldehyde dehydrogenase (NAD) activity molecular function
aldehyde dehydrogenase [NAD(P)+] activity 1.20924 Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895]
4.40797 Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]
amino acid metabolic process 1.19539 up Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). [Uniprot/SWISSPROT;Acc:Q9Y697] biological process
1.40552 down Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76]
1.75846 Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]
amino acid transport 1.40552 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76]
amino acid transporter activity molecular function
aminoacyl-tRNA ligase activity 2.25955 Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Uniprot/SWISSPROT;Acc:Q9BW92]
aminopeptidase activity 1.76583 leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]
anagen 1.18096 Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354] biological process
anatomical structure development 3.70292 up Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]
anatomical structure morphogenesis 1.27461 down Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]
1.61987 up Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]
angiogenesis 1.36997 Rho GTPase-activating protein 24 (Rho-type GTPase-activating protein 24) (Filamin-A-associated RhoGAP) (FilGAP) (p73RhoGAP) (RhoGAP of 73 kDa) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Sarcoma antigen NY-SAR-88). [Uniprot/SWISSPROT;Acc:Q8N264]
anion exchanger activity 1.31661 Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879] molecular function
2.88235 down Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751]
anion transport 1.13007 up Zinc finger protein 219. [Uniprot/SWISSPROT;Acc:Q9P2Y4] biological process
1.31661 Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879]
2.88235 down Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751]
anterior/posterior pattern formation 2.69364 up Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase). [Uniprot/SWISSPROT;Acc:O43174]
anti-apoptosis 1.98149 CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]
antigen processing and presentation of endogenous peptide antigen via MHC class I 1.76583 down leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]
antiporter activity 1.31661 up Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879] molecular function
2.88235 down Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751]
AP-1 adaptor complex 1.30207 Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96] cellular component
AP-2 adaptor complex
apical junction complex 1.4628 up Poliovirus receptor-related protein 3 precursor (Nectin-3) (CD113 antigen) (CDw113). [Uniprot/SWISSPROT;Acc:Q9NQS3]
apical plasma membrane 1.31661 Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879]
apoptosis 1.19545 Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Uniprot/SWISSPROT;Acc:O00115] biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/