Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
p Ratio description Accession neuronal
Results: HTML CSV LaTeX Showing element 1 to 50 of 201 in total
Ratio: up
\def\wcA{0.25\textwidth} \def\wcB{0.25\textwidth} \def\wcC{0.25\textwidth} \begin{longtable}{|c|c|c|} \hline \parbox{\wcA}{\vspace{3pt}\noindent p\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent description\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent neuronal\vspace{3pt}}\\ \hline \hline \multirow{9}{*}{\parbox{\wcA}{\vspace{3pt}\noindent 0\vspace{3pt}}}&\parbox{\wcB}{\vspace{3pt}\noindent cytoplasmic vesicle\vspace{3pt}}&\multirow{28}{*}{\parbox{\wcC}{\vspace{3pt}\noindent \vspace{3pt}}}\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent dephosphorylation\vspace{3pt}}&\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent homoiothermy\vspace{3pt}}&\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent ice binding\vspace{3pt}}&\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent membrane\vspace{3pt}}&\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent protein binding\vspace{3pt}}&\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent response to freezing\vspace{3pt}}&\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent response to stimulus\vspace{3pt}}&\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent small conjugating protein ligase activity\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.00000000000532447\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent cytoplasm\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.000000005351\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent cell junction\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.0000000131078\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent RNA splicing\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.0000000750539\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent Golgi apparatus\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.00000117775\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent regulation of progression through cell cycle\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.00000824263\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent structural constituent of cell wall\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.0000171601\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent protein kinase activity\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.0000189325\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent phosphoric monoester hydrolase activity\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.0000244289\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent cell-cell signaling\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.0000321095\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent membrane fraction\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.0000520983\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent integral to plasma membrane\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.0000791323\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent protein C-terminus binding\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.000237102\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent nucleocytoplasmic transport\vspace{3pt}}&\\\cline{1-2} \multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent 0.000408197\vspace{3pt}}}&\parbox{\wcB}{\vspace{3pt}\noindent flagellin-based flagellum\vspace{3pt}}&\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent mRNA transport\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.000762333\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent protein dimerization activity\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.000793622\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent GTPase activity\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.000857538\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent glycerol metabolic process\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.000975592\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent transcription\vspace{3pt}}&\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 0.00115531\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent neuropeptide hormone activity\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 1\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 0.00141209\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent extracellular region\vspace{3pt}}&\multirow{17}{*}{\parbox{\wcC}{\vspace{3pt}\noindent \vspace{3pt}}}\\\cline{1-2} \multirow{3}{*}{\parbox{\wcA}{\vspace{3pt}\noindent 0.00235127\vspace{3pt}}}&\parbox{\wcB}{\vspace{3pt}\noindent anion exchanger activity\vspace{3pt}}&\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent arylamine N-acetyltransferase activity\vspace{3pt}}&\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent ciliary or flagellar motility\vspace{3pt}}&\\\cline{1-2} \multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent 0.0025796\vspace{3pt}}}&\parbox{\wcB}{\vspace{3pt}\noindent positive regulation of transcription\vspace{3pt}}&\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent regulation of transcription from RNA polymerase II promoter\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.00308834\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent identical protein binding\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.00356939\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent signal transduction\vspace{3pt}}&\\\cline{1-2} \multirow{5}{*}{\parbox{\wcA}{\vspace{3pt}\noindent 0.00383965\vspace{3pt}}}&\parbox{\wcB}{\vspace{3pt}\noindent aldehyde dehydrogenase [NAD(P)+] activity\vspace{3pt}}&\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent histamine receptor activity\vspace{3pt}}&\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent interleukin-1 receptor activity\vspace{3pt}}&\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent membrane coat\vspace{3pt}}&\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent nucleoside transporter activity\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.00391116\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent soluble fraction\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.00425207\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent cell cycle\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.00504034\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent mitosis\vspace{3pt}}&\\\cline{1-2} \multirow{4}{*}{\parbox{\wcA}{\vspace{3pt}\noindent 0.00564318\vspace{3pt}}}&\parbox{\wcB}{\vspace{3pt}\noindent circulation\vspace{3pt}}&\\\cline{2-3} &\parbox{\wcB}{\vspace{3pt}\noindent dopamine receptor activity\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 1\vspace{3pt}}\\\cline{2-3} &\parbox{\wcB}{\vspace{3pt}\noindent ligand-dependent nuclear receptor activity\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent \vspace{3pt}}}\\\cline{2-2} &\parbox{\wcB}{\vspace{3pt}\noindent positive regulation of I-kappaB kinase/NF-kappaB cascade\vspace{3pt}}&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 0.00614065\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent RNA polymerase II transcription factor activity\vspace{3pt}}&\\\hline nd{longtable}
Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.

- http://analysis.yellowcouch.org/