Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

p Ratio description Accession neuronal

Results: HTML CSV LaTeX

Showing element 1 to 50 of 220 in total

neuronal: 

\def\wcA{0.25\textwidth}
\def\wcB{0.25\textwidth}
\def\wcC{0.25\textwidth}
\begin{longtable}{|c|c|c|}
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
p\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
Ratio\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
description\vspace{3pt}}\\
\hline
\hline
\multirow{10}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
0\vspace{3pt}}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
nucleus\vspace{3pt}}\\\cline{2-3}
&\multirow{9}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
cytoplasmic vesicle\vspace{3pt}}\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
dephosphorylation\vspace{3pt}}\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
homoiothermy\vspace{3pt}}\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
ice binding\vspace{3pt}}\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
protein binding\vspace{3pt}}\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
response to freezing\vspace{3pt}}\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
response to stimulus\vspace{3pt}}\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
small conjugating protein ligase activity\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.04188e-19\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
catalytic activity\vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
4.41122e-18\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
extracellular space\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.00000000000532447\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
cytoplasm\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.0000000000369233\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
receptor activity\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.000000005351\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
cell junction\vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0000000131078\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
RNA splicing\vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0000000750539\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Golgi apparatus\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.000000819712\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
structural constituent of ribosome\vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.000000909018\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.00000117775\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
regulation of progression through cell cycle\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.00000144966\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
nucleic acid binding\vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00000618855\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
translation\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.00000824263\vspace{3pt}}&\multirow{4}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
structural constituent of cell wall\vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0000171601\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
protein kinase activity\vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0000189325\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
phosphoric monoester hydrolase activity\vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0000244289\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
cell-cell signaling\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.0000251477\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
ribosome\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.0000321095\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
membrane fraction\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.0000325409\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
G-protein coupled receptor protein signaling pathway\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.0000520983\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
integral to plasma membrane\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.0000603978\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
protein ubiquitination\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.0000791323\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
protein C-terminus binding\vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.000237102\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
nucleocytoplasmic transport\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.00038871\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
external side of plasma membrane\vspace{3pt}}\\\hline
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
0.000408197\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
flagellin-based flagellum\vspace{3pt}}\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
mRNA transport\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.000541705\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
ubiquitin ligase complex\vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.000654237\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
zinc ion binding\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.000762333\vspace{3pt}}&\multirow{4}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
protein dimerization activity\vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.000793622\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
GTPase activity\vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.000857538\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
glycerol metabolic process\vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.000975592\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
transcription\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.00123417\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
ATP binding\vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00127674\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
antigen binding\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.00141209\vspace{3pt}}&\multirow{4}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
extracellular region\vspace{3pt}}\\\cline{1-1}\cline{3-3}
\multirow{3}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
0.00235127\vspace{3pt}}}&&\parbox{\wcC}{\vspace{3pt}\noindent
anion exchanger activity\vspace{3pt}}\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
arylamine N-acetyltransferase activity\vspace{3pt}}\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
ciliary or flagellar motility\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.00245746\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
NAD binding\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.0025796\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
positive regulation of transcription\vspace{3pt}}\\\hline
nd{longtable}

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.

 - Accession is the GO accession key. 

 - Part of neuralk circuitery.

- http://analysis.yellowcouch.org/