MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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p	Ratio	description	Accession	neuronal

Results: HTML CSV LaTeX

Showing element 51 to 100 of 239 in total

p	Ratio	description	neuronal
0.0395988	up	Toll binding	no value
0.0382916		transcription from RNA polymerase II promoter
0.0377184	down	transferase activity
0.0374953	up	transcription factor activity
0.037387		plasma membrane
0.0369324		cell adhesion
0.0368141		antiporter activity
		inorganic anion exchanger activity
		negative regulation of protein kinase activity
0.0354267		lipid metabolic process
0.0350815	down	gamete generation
0.0340565	up	inner ear morphogenesis
0.0338741		protein homodimerization activity
0.0335097		ubiquitin cycle
0.0328763		ribonuclease activity
0.0322278		nucleotide binding
0.0291865	down	DNA replication
0.02908	up	calcium channel regulator activity	1
0.028596	down	integrase activity	no value
0.0280274	up	synapse	1
0.0262113		anion transport	no value
		neurotransmitter:sodium symporter activity	1
0.0254395		integral to Golgi membrane	no value
		response to drug
		transcription cofactor activity
0.024391		protein complex assembly
0.023627		hormone activity
0.0216681	down	kinase activity
0.0206183		microtubule-based movement
0.0204393		proteolysis
0.0202076	up	AP-2 adaptor complex
		ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
		beta-galactoside alpha-2,3-sialyltransferase activity
		beta-mannosidase activity
		camera-type eye development
		carotenoid biosynthetic process
		CD40 receptor binding
		centrosome duplication
		clathrin binding
		cytoplasmic chromatin
		cytoskeletal anchoring
		delayed rectifier potassium channel activity
		detection of stimulus during sensory perception	1
		endodeoxyribonuclease activity	no value
		extracellular matrix binding
		glyoxylate cycle
		interleukin-1 receptor complex
		interleukin-18 receptor complex
		leading edge cell differentiation
		leukocyte activation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.