Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.


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p Ratio description Accession neuronal
Results: HTML CSV LaTeX Showing element 1 to 50 of 239 in total 
p	Ratio	description	neuronal	
0	down	nucleus		
0	up	cytoplasmic vesicle		
0	up	dephosphorylation		
0	up	homoiothermy		
0	up	ice binding		
0	up	membrane		
0	up	protein binding		
0	up	response to freezing		
0	up	response to stimulus		
0	up	small conjugating protein ligase activity		
1.04188e-19	down	catalytic activity		
4.41122e-18	down	extracellular space		
0.00000000000532447	up	cytoplasm		
0.0000000000369233	down	receptor activity		
0.000000005351	up	cell junction		
0.0000000131078	up	RNA splicing		
0.0000000750539	up	Golgi apparatus		
0.000000227862	down	olfactory receptor activity	1	
0.000000819712	down	structural constituent of ribosome		
0.000000909018	down	integral to membrane		
0.00000117775	up	regulation of progression through cell cycle		
0.00000144966	down	nucleic acid binding		
0.00000618855	down	translation		
0.00000824263	up	structural constituent of cell wall		
0.0000171601	up	protein kinase activity		
0.0000189325	up	phosphoric monoester hydrolase activity		
0.0000244289	up	cell-cell signaling		
0.0000251477	down	ribosome		
0.0000321095	up	membrane fraction		
0.0000325409	down	G-protein coupled receptor protein signaling pathway		
0.0000520983	up	integral to plasma membrane		
0.0000603978	down	protein ubiquitination		
0.0000791323	up	protein C-terminus binding		
0.000237102	up	nucleocytoplasmic transport		
0.00038871	down	external side of plasma membrane		
0.000408197	up	flagellin-based flagellum		
0.000408197	up	mRNA transport		
0.000541705	down	ubiquitin ligase complex		
0.000654237	down	zinc ion binding		
0.000762333	up	protein dimerization activity		
0.000793622	up	GTPase activity		
0.000857538	up	glycerol metabolic process		
0.000975592	up	transcription		
0.00115531	up	neuropeptide hormone activity	1	
0.00123417	down	ATP binding		
0.00127674	down	antigen binding		
0.00141209	up	extracellular region		
0.00235127	up	anion exchanger activity		
0.00235127	up	arylamine N-acetyltransferase activity		
0.00235127	up	ciliary or flagellar motility		

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Part of neuralk circuitery.
- http://analysis.yellowcouch.org/