Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.


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p description Ratio Accession neuronal
Results: HTML CSV LaTeX Showing element 1 to 50 of 239 in total 
p	description	Ratio	neuronal	
0	cytoplasmic vesicle	up		
0	dephosphorylation	up		
0	homoiothermy	up		
0	ice binding	up		
0	membrane	up		
0	nucleus	down		
0	protein binding	up		
0	response to freezing	up		
0	response to stimulus	up		
0	small conjugating protein ligase activity	up		
1.04188e-19	catalytic activity	down		
4.41122e-18	extracellular space	down		
0.00000000000532447	cytoplasm	up		
0.0000000000369233	receptor activity	down		
0.000000005351	cell junction	up		
0.0000000131078	RNA splicing	up		
0.0000000750539	Golgi apparatus	up		
0.000000227862	olfactory receptor activity	down	1	
0.000000819712	structural constituent of ribosome	down		
0.000000909018	integral to membrane	down		
0.00000117775	regulation of progression through cell cycle	up		
0.00000144966	nucleic acid binding	down		
0.00000618855	translation	down		
0.00000824263	structural constituent of cell wall	up		
0.0000171601	protein kinase activity	up		
0.0000189325	phosphoric monoester hydrolase activity	up		
0.0000244289	cell-cell signaling	up		
0.0000251477	ribosome	down		
0.0000321095	membrane fraction	up		
0.0000325409	G-protein coupled receptor protein signaling pathway	down		
0.0000520983	integral to plasma membrane	up		
0.0000603978	protein ubiquitination	down		
0.0000791323	protein C-terminus binding	up		
0.000237102	nucleocytoplasmic transport	up		
0.00038871	external side of plasma membrane	down		
0.000408197	flagellin-based flagellum	up		
0.000408197	mRNA transport	up		
0.000541705	ubiquitin ligase complex	down		
0.000654237	zinc ion binding	down		
0.000762333	protein dimerization activity	up		
0.000793622	GTPase activity	up		
0.000857538	glycerol metabolic process	up		
0.000975592	transcription	up		
0.00115531	neuropeptide hormone activity	up	1	
0.00123417	ATP binding	down		
0.00127674	antigen binding	down		
0.00141209	extracellular region	up		
0.00235127	anion exchanger activity	up		
0.00235127	arylamine N-acetyltransferase activity	up		
0.00235127	ciliary or flagellar motility	up		

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Part of neuralk circuitery.
- http://analysis.yellowcouch.org/