MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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p	Ratio	description	Accession	neuronal

Results: HTML CSV LaTeX

Showing element 1 to 50 of 239 in total

Ratio  : up

p	description	neuronal
0.0493456	cell growth	no value
0.0483241	chromatin binding
0.0473076	calcium channel activity
0.0470779	transcriptional activator activity
0.0431445	metal ion binding
0.0404804	amino acid metabolic process
0.0402868	protein amino acid dephosphorylation
0.0395988	Toll binding
	STAT protein nuclear translocation
	retinoic acid receptor signaling pathway
	response to sterol depletion
	response to cold
	regulation of inflammatory response
	regulation of cyclin-dependent protein kinase activity
	protein phosphatase type 1 complex
	protein amino acid lipidation
	prostaglandin-endoperoxide synthase activity
	positive regulation of viral genome replication
	positive regulation of mitosis
	positive regulation of meiosis
	phosphoinositide-mediated signaling
	phosphatidylinositol N-acetylglucosaminyltransferase activity
	peroxisome organization and biogenesis
	oxidized purine base lesion DNA N-glycosylase activity
	orexin receptor activity
	nuclear organization and biogenesis
	neuropeptide receptor activity	1
	myoblast fusion	no value
	monoamine transport
	mitotic G2 checkpoint
	mitochondrial small ribosomal subunit
	methylated-DNA-[protein]-cysteine S-methyltransferase activity
	mannosidase activity
	iron-sulfur cluster binding
	intercellular junction maintenance
	integral to peroxisomal membrane
	hemostasis
	growth hormone secretion
	glycosaminoglycan binding
	generation of precursor metabolites and energy
	female pronucleus
	embryonic arm morphogenesis
	deoxyribonuclease II activity
	ceramide biosynthetic process
	cellular protein metabolic process
	cannabinoid receptor activity	1
	axon ensheathment
	apical junction complex	no value
	adult heart development
	activation of MAPKK activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.