MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

Navigation/Query Panel:
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p	Ratio	description	Accession	neuronal

Results: HTML CSV LaTeX

Showing element 1 to 38 of 38 in total

Ratio  : down

p	description	neuronal
0	nucleus	no value
1.04188e-19	catalytic activity
4.41122e-18	extracellular space
0.0000000000369233	receptor activity
0.000000227862	olfactory receptor activity	1
0.000000819712	structural constituent of ribosome	no value
0.000000909018	integral to membrane
0.00000144966	nucleic acid binding
0.00000618855	translation
0.0000251477	ribosome
0.0000325409	G-protein coupled receptor protein signaling pathway
0.0000603978	protein ubiquitination
0.00038871	external side of plasma membrane
0.000541705	ubiquitin ligase complex
0.000654237	zinc ion binding
0.00123417	ATP binding
0.00127674	antigen binding
0.00245746	NAD binding
0.00273397	ubiquitin-protein ligase activity
0.00362499	metabotropic glutamate receptor signaling pathway	1
0.00369746	glycolysis	no value
0.0040154	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity
0.00718696	regulation of transcription, DNA-dependent
0.00803044	binding
0.00965867	mitochondrion
0.0105006	trypsin activity
0.01078	Golgi stack
0.0111584	metabotropic glutamate, GABA-B-like receptor activity	1
0.0175073	chymotrypsin activity	no value
0.0189449	electron transport
0.0197922	sensory perception	1
0.0204393	proteolysis	no value
0.0206183	microtubule-based movement
0.0216681	kinase activity
0.028596	integrase activity
0.0291865	DNA replication
0.0350815	gamete generation
0.0377184	transferase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.