MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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Ratio	neuronal	description	p	Accession

Results: HTML CSV LaTeX

Showing element 22 to 71 of 239 in total

Ratio	neuronal	description	p
down	no value	nucleus	0
		protein ubiquitination	0.0000603978
		proteolysis	0.0204393
		receptor activity	0.0000000000369233
		regulation of transcription, DNA-dependent	0.00718696
		ribosome	0.0000251477
		structural constituent of ribosome	0.000000819712
		transferase activity	0.0377184
		translation	0.00000618855
		trypsin activity	0.0105006
		ubiquitin ligase complex	0.000541705
		ubiquitin-protein ligase activity	0.00273397
		zinc ion binding	0.000654237
	1	metabotropic glutamate receptor signaling pathway	0.00362499
		metabotropic glutamate, GABA-B-like receptor activity	0.0111584
		olfactory receptor activity	0.000000227862
		sensory perception	0.0197922
up	no value	7S RNA binding	0.0395988
		acetyltransferase activity	0.00774091
		activation of MAPKK activity	0.0395988
		adult heart development
		aldehyde dehydrogenase [NAD(P)+] activity	0.00383965
		amino acid metabolic process	0.0404804
		anatomical structure morphogenesis	0.0101128
		anion exchanger activity	0.00235127
		anion transport	0.0262113
		antiporter activity	0.0368141
		AP-2 adaptor complex	0.0202076
		apical junction complex	0.0395988
		arylamine N-acetyltransferase activity	0.00235127
		ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity	0.0202076
		beta-galactoside alpha-2,3-sialyltransferase activity
		beta-mannosidase activity
		calcium channel activity	0.0473076
		calmodulin binding	0.0109353
		camera-type eye development	0.0202076
		carotenoid biosynthetic process
		CD40 receptor binding
		cell adhesion	0.0369324
		cell cycle	0.00425207
		cell growth	0.0493456
		cell junction	0.000000005351
		cell motility	0.0192954
		cell proliferation	0.011406
		cell-cell signaling	0.0000244289
		cellular protein metabolic process	0.0395988
		centrosome duplication	0.0202076
		ceramide biosynthetic process	0.0395988
		chromatin binding	0.0483241
		chromosome, pericentric region	0.00970846

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.