Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.


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p Ratio description Accession neuronal
Results: HTML CSV LaTeX Showing element 51 to 100 of 239 in total 
p	Ratio	description	neuronal	
0.00245746	down	NAD binding		
0.0025796	up	positive regulation of transcription		
0.0025796	up	regulation of transcription from RNA polymerase II promoter		
0.00273397	down	ubiquitin-protein ligase activity		
0.00308834	up	identical protein binding		
0.00356939	up	signal transduction		
0.00362499	down	metabotropic glutamate receptor signaling pathway	1	
0.00369746	down	glycolysis		
0.00383965	up	aldehyde dehydrogenase [NAD(P)+] activity		
0.00383965	up	histamine receptor activity		
0.00383965	up	interleukin-1 receptor activity		
0.00383965	up	membrane coat		
0.00383965	up	nucleoside transporter activity		
0.00391116	up	soluble fraction		
0.0040154	down	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity		
0.00425207	up	cell cycle		
0.00504034	up	mitosis		
0.00564318	up	circulation		
0.00564318	up	dopamine receptor activity	1	
0.00564318	up	ligand-dependent nuclear receptor activity		
0.00564318	up	positive regulation of I-kappaB kinase/NF-kappaB cascade		
0.00614065	up	RNA polymerase II transcription factor activity		
0.00664368	up	negative regulation of cell growth		
0.00670433	up	voltage-gated ion channel activity	1	
0.00718696	down	regulation of transcription, DNA-dependent		
0.00726676	up	multicellular organismal development		
0.00759448	up	protein serine/threonine phosphatase activity		
0.00774091	up	acetyltransferase activity		
0.00774091	up	electron carrier activity	1	
0.00774091	up	ER-Golgi intermediate compartment		
0.00774091	up	guanyl nucleotide binding		
0.00774091	up	positive regulation of body size		
0.00774091	up	retinoic acid metabolic process		
0.00803044	down	binding		
0.00833399	up	regulation of transcription		
0.00836988	up	intracellular		
0.00878703	up	nervous system development	1	
0.00916333	up	visual perception	1	
0.00965867	down	mitochondrion		
0.00970846	up	chromosome, pericentric region		
0.0100316	up	potassium ion binding	1	
0.0101128	up	anatomical structure morphogenesis		
0.0101128	up	humoral immune response		
0.0105006	down	trypsin activity		
0.0107462	up	microtubule binding		
0.01078	down	Golgi stack		
0.0108714	up	nucleoplasm		
0.0109032	up	endoplasmic reticulum		
0.0109353	up	calmodulin binding		
0.0111584	down	metabotropic glutamate, GABA-B-like receptor activity	1	

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Part of neuralk circuitery.
- http://analysis.yellowcouch.org/