Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

p Ratio description Accession neuronal

Results: HTML CSV LaTeX

Showing element 1 to 50 of 239 in total

Ratio: up

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\begin{longtable}{|c|c|c|}
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
p\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
description\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
neuronal\vspace{3pt}}\\
\hline
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.0493456\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
cell growth\vspace{3pt}}&\multirow{11}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
\vspace{3pt}}}\\\cline{1-2}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0483241\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
chromatin binding\vspace{3pt}}&\\\cline{1-2}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0473076\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
calcium channel activity\vspace{3pt}}&\\\cline{1-2}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0470779\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
transcriptional activator activity\vspace{3pt}}&\\\cline{1-2}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0431445\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
metal ion binding\vspace{3pt}}&\\\cline{1-2}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0404804\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
amino acid metabolic process\vspace{3pt}}&\\\cline{1-2}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0402868\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
protein amino acid dephosphorylation\vspace{3pt}}&\\\cline{1-2}
\multirow{43}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
0.0395988\vspace{3pt}}}&\parbox{\wcB}{\vspace{3pt}\noindent
7S RNA binding\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
activation of MAPKK activity\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
adult heart development\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
apical junction complex\vspace{3pt}}&\\\cline{2-3}
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axon ensheathment\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
1\vspace{3pt}}}\\\cline{2-2}
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cannabinoid receptor activity\vspace{3pt}}&\\\cline{2-3}
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cellular protein metabolic process\vspace{3pt}}&\multirow{18}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
\vspace{3pt}}}\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
ceramide biosynthetic process\vspace{3pt}}&\\\cline{2-2}
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deoxyribonuclease II activity\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
embryonic arm morphogenesis\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
female pronucleus\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
generation of precursor metabolites and energy\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
glycosaminoglycan binding\vspace{3pt}}&\\\cline{2-2}
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growth hormone secretion\vspace{3pt}}&\\\cline{2-2}
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hemostasis\vspace{3pt}}&\\\cline{2-2}
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integral to peroxisomal membrane\vspace{3pt}}&\\\cline{2-2}
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intercellular junction maintenance\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
iron-sulfur cluster binding\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
mannosidase activity\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
methylated-DNA-[protein]-cysteine S-methyltransferase activity\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
mitochondrial small ribosomal subunit\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
mitotic G2 checkpoint\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
monoamine transport\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
myoblast fusion\vspace{3pt}}&\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
neuropeptide receptor activity\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1\vspace{3pt}}\\\cline{2-3}
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nuclear organization and biogenesis\vspace{3pt}}&\multirow{18}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
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&\parbox{\wcB}{\vspace{3pt}\noindent
orexin receptor activity\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
oxidized purine base lesion DNA N-glycosylase activity\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
peroxisome organization and biogenesis\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
phosphatidylinositol N-acetylglucosaminyltransferase activity\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
phosphoinositide-mediated signaling\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
positive regulation of meiosis\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
positive regulation of mitosis\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
positive regulation of viral genome replication\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
prostaglandin-endoperoxide synthase activity\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
protein amino acid lipidation\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
protein phosphatase type 1 complex\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
regulation of cyclin-dependent protein kinase activity\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
regulation of inflammatory response\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
response to cold\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
response to sterol depletion\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
retinoic acid receptor signaling pathway\vspace{3pt}}&\\\cline{2-2}
&\parbox{\wcB}{\vspace{3pt}\noindent
STAT protein nuclear translocation\vspace{3pt}}&\\\hline
nd{longtable}

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.

 - Accession is the GO accession key. 

 - Part of neuralk circuitery.

- http://analysis.yellowcouch.org/