MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	description	p	Accession	neuronal

Results: HTML CSV LaTeX

Showing element 191 to 239 of 239 in total

Ratio  : up

description	p	neuronal
protein homodimerization activity	0.0338741	no value
protein kinase activity	0.0000171601
protein kinase C inhibitor activity	0.0202076
protein modification process	0.0168307
protein phosphatase type 1 complex	0.0395988
protein phosphatase type 2A activity	0.0202076
protein serine/threonine phosphatase activity	0.00759448
protein transport	0.0148187
regulation of cyclin-dependent protein kinase activity	0.0395988
regulation of inflammatory response
regulation of progression through cell cycle	0.00000117775
regulation of transcription	0.00833399
regulation of transcription from RNA polymerase II promoter	0.0025796
regulation of viral transcription	0.0202076
response to cold	0.0395988
response to drug	0.0254395
response to freezing	0
response to oxidative stress	0.0189851
response to sterol depletion	0.0395988
response to stimulus	0
retinoic acid metabolic process	0.00774091
retinoic acid receptor signaling pathway	0.0395988
ribonuclease activity	0.0328763
RNA lariat debranching enzyme activity	0.0202076
RNA polymerase II transcription factor activity	0.00614065
RNA splicing	0.0000000131078
selenocysteine incorporation	0.0202076
sensory perception of sound	0.0159483	1
signal transduction	0.00356939	no value
small conjugating protein ligase activity	0
sodium:dicarboxylate symporter activity	0.0127396
soluble fraction	0.00391116
STAT protein nuclear translocation	0.0395988
structural constituent of cell wall	0.00000824263
synapse	0.0280274	1
Toll binding	0.0395988	no value
transcription	0.000975592
transcription cofactor activity	0.0254395
transcription factor activity	0.0374953
transcription from RNA polymerase II promoter	0.0382916
transcription from RNA polymerase III promoter	0.0202076
transcriptional activator activity	0.0470779
transport vesicle	0.0202076
tyrosine phosphorylation of STAT protein
ubiquitin cycle	0.0335097
visual perception	0.00916333	1
vitamin D receptor binding	0.0202076	no value
voltage-gated ion channel activity	0.00670433	1
zygotic determination of anterior/posterior axis, embryo	0.0202076	no value

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.