Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.


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Ratio description p Accession neuronal
Results: HTML CSV LaTeX Showing element 1 to 50 of 239 in total 
Ratio	description	p	neuronal	
down	antigen binding	0.00127674		
down	ATP binding	0.00123417		
down	binding	0.00803044		
down	catalytic activity	1.04188e-19		
down	chymotrypsin activity	0.0175073		
down	DNA replication	0.0291865		
down	electron transport	0.0189449		
down	external side of plasma membrane	0.00038871		
down	extracellular space	4.41122e-18		
down	G-protein coupled receptor protein signaling pathway	0.0000325409		
down	gamete generation	0.0350815		
down	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	0.0040154		
down	glycolysis	0.00369746		
down	Golgi stack	0.01078		
down	integral to membrane	0.000000909018		
down	integrase activity	0.028596		
down	kinase activity	0.0216681		
down	metabotropic glutamate receptor signaling pathway	0.00362499	1	
down	metabotropic glutamate, GABA-B-like receptor activity	0.0111584	1	
down	microtubule-based movement	0.0206183		
down	mitochondrion	0.00965867		
down	NAD binding	0.00245746		
down	nucleic acid binding	0.00000144966		
down	nucleus	0		
down	olfactory receptor activity	0.000000227862	1	
down	protein ubiquitination	0.0000603978		
down	proteolysis	0.0204393		
down	receptor activity	0.0000000000369233		
down	regulation of transcription, DNA-dependent	0.00718696		
down	ribosome	0.0000251477		
down	sensory perception	0.0197922	1	
down	structural constituent of ribosome	0.000000819712		
down	transferase activity	0.0377184		
down	translation	0.00000618855		
down	trypsin activity	0.0105006		
down	ubiquitin ligase complex	0.000541705		
down	ubiquitin-protein ligase activity	0.00273397		
down	zinc ion binding	0.000654237		
up	7S RNA binding	0.0395988		
up	acetyltransferase activity	0.00774091		
up	activation of MAPKK activity	0.0395988		
up	adult heart development	0.0395988		
up	aldehyde dehydrogenase [NAD(P)+] activity	0.00383965		
up	amino acid metabolic process	0.0404804		
up	anatomical structure morphogenesis	0.0101128		
up	anion exchanger activity	0.00235127		
up	anion transport	0.0262113		
up	antiporter activity	0.0368141		
up	AP-2 adaptor complex	0.0202076		
up	apical junction complex	0.0395988		

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Part of neuralk circuitery.
- http://analysis.yellowcouch.org/