Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.


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p Ratio description Accession neuronal
Results: HTML CSV LaTeX Showing element 191 to 239 of 239 in total 
Ratio	up

p	description	neuronal	
0.0395988	adult heart development		
0.0395988	apical junction complex		
0.0395988	axon ensheathment	1	
0.0395988	cannabinoid receptor activity	1	
0.0395988	cellular protein metabolic process		
0.0395988	ceramide biosynthetic process		
0.0395988	deoxyribonuclease II activity		
0.0395988	embryonic arm morphogenesis		
0.0395988	female pronucleus		
0.0395988	generation of precursor metabolites and energy		
0.0395988	glycosaminoglycan binding		
0.0395988	growth hormone secretion		
0.0395988	hemostasis		
0.0395988	integral to peroxisomal membrane		
0.0395988	intercellular junction maintenance		
0.0395988	iron-sulfur cluster binding		
0.0395988	mannosidase activity		
0.0395988	methylated-DNA-[protein]-cysteine S-methyltransferase activity		
0.0395988	mitochondrial small ribosomal subunit		
0.0395988	mitotic G2 checkpoint		
0.0395988	monoamine transport		
0.0395988	myoblast fusion		
0.0395988	neuropeptide receptor activity	1	
0.0395988	nuclear organization and biogenesis		
0.0395988	orexin receptor activity		
0.0395988	oxidized purine base lesion DNA N-glycosylase activity		
0.0395988	peroxisome organization and biogenesis		
0.0395988	phosphatidylinositol N-acetylglucosaminyltransferase activity		
0.0395988	phosphoinositide-mediated signaling		
0.0395988	positive regulation of meiosis		
0.0395988	positive regulation of mitosis		
0.0395988	positive regulation of viral genome replication		
0.0395988	prostaglandin-endoperoxide synthase activity		
0.0395988	protein amino acid lipidation		
0.0395988	protein phosphatase type 1 complex		
0.0395988	regulation of cyclin-dependent protein kinase activity		
0.0395988	regulation of inflammatory response		
0.0395988	response to cold		
0.0395988	response to sterol depletion		
0.0395988	retinoic acid receptor signaling pathway		
0.0395988	STAT protein nuclear translocation		
0.0395988	Toll binding		
0.0402868	protein amino acid dephosphorylation		
0.0404804	amino acid metabolic process		
0.0431445	metal ion binding		
0.0470779	transcriptional activator activity		
0.0473076	calcium channel activity		
0.0483241	chromatin binding		
0.0493456	cell growth		

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Part of neuralk circuitery.
- http://analysis.yellowcouch.org/