MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

description	Accession	Ratio	neuronal	p

Results: HTML CSV LaTeX

Showing element 191 to 239 of 239 in total

description	Ratio	neuronal	p
regulation of progression through cell cycle	up	no value	0.00000117775
regulation of transcription			0.00833399
regulation of transcription from RNA polymerase II promoter			0.0025796
regulation of transcription, DNA-dependent	down		0.00718696
regulation of viral transcription	up		0.0202076
response to cold			0.0395988
response to drug			0.0254395
response to freezing			0
response to oxidative stress			0.0189851
response to sterol depletion			0.0395988
response to stimulus			0
retinoic acid metabolic process			0.00774091
retinoic acid receptor signaling pathway			0.0395988
ribonuclease activity			0.0328763
ribosome	down		0.0000251477
RNA lariat debranching enzyme activity	up		0.0202076
RNA polymerase II transcription factor activity			0.00614065
RNA splicing			0.0000000131078
selenocysteine incorporation			0.0202076
sensory perception	down	1	0.0197922
sensory perception of sound	up		0.0159483
signal transduction		no value	0.00356939
small conjugating protein ligase activity			0
sodium:dicarboxylate symporter activity			0.0127396
soluble fraction			0.00391116
STAT protein nuclear translocation			0.0395988
structural constituent of cell wall			0.00000824263
structural constituent of ribosome	down		0.000000819712
synapse	up	1	0.0280274
Toll binding		no value	0.0395988
transcription			0.000975592
transcription cofactor activity			0.0254395
transcription factor activity			0.0374953
transcription from RNA polymerase II promoter			0.0382916
transcription from RNA polymerase III promoter			0.0202076
transcriptional activator activity			0.0470779
transferase activity	down		0.0377184
translation			0.00000618855
transport vesicle	up		0.0202076
trypsin activity	down		0.0105006
tyrosine phosphorylation of STAT protein	up		0.0202076
ubiquitin cycle			0.0335097
ubiquitin ligase complex	down		0.000541705
ubiquitin-protein ligase activity			0.00273397
visual perception	up	1	0.00916333
vitamin D receptor binding		no value	0.0202076
voltage-gated ion channel activity		1	0.00670433
zinc ion binding	down	no value	0.000654237
zygotic determination of anterior/posterior axis, embryo	up		0.0202076

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.