MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	description	p	Accession	neuronal

Results: HTML CSV LaTeX

Showing element 1 to 50 of 239 in total

Ratio	description	p	neuronal
down	antigen binding	0.00127674	no value
	ATP binding	0.00123417
	binding	0.00803044
	catalytic activity	1.04188e-19
	chymotrypsin activity	0.0175073
	DNA replication	0.0291865
	electron transport	0.0189449
	external side of plasma membrane	0.00038871
	extracellular space	4.41122e-18
	G-protein coupled receptor protein signaling pathway	0.0000325409
	gamete generation	0.0350815
	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	0.0040154
	glycolysis	0.00369746
	Golgi stack	0.01078
	integral to membrane	0.000000909018
	integrase activity	0.028596
	kinase activity	0.0216681
	metabotropic glutamate receptor signaling pathway	0.00362499	1
	metabotropic glutamate, GABA-B-like receptor activity	0.0111584
	microtubule-based movement	0.0206183	no value
	mitochondrion	0.00965867
	NAD binding	0.00245746
	nucleic acid binding	0.00000144966
	nucleus	0
	olfactory receptor activity	0.000000227862	1
	protein ubiquitination	0.0000603978	no value
	proteolysis	0.0204393
	receptor activity	0.0000000000369233
	regulation of transcription, DNA-dependent	0.00718696
	ribosome	0.0000251477
	sensory perception	0.0197922	1
	structural constituent of ribosome	0.000000819712	no value
	transferase activity	0.0377184
	translation	0.00000618855
	trypsin activity	0.0105006
	ubiquitin ligase complex	0.000541705
	ubiquitin-protein ligase activity	0.00273397
	zinc ion binding	0.000654237
up	7S RNA binding	0.0395988
	acetyltransferase activity	0.00774091
	activation of MAPKK activity	0.0395988
	adult heart development
	aldehyde dehydrogenase [NAD(P)+] activity	0.00383965
	amino acid metabolic process	0.0404804
	anatomical structure morphogenesis	0.0101128
	anion exchanger activity	0.00235127
	anion transport	0.0262113
	antiporter activity	0.0368141
	AP-2 adaptor complex	0.0202076
	apical junction complex	0.0395988

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.