Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

p Ratio description Accession neuronal

Results: HTML CSV LaTeX

Showing element 51 to 100 of 239 in total


\def\wcA{0.2\textwidth}
\def\wcB{0.2\textwidth}
\def\wcC{0.2\textwidth}
\def\wcD{0.2\textwidth}
\begin{longtable}{|c|c|c|c|}
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
p\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
Ratio\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
description\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
neuronal\vspace{3pt}}\\
\hline
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.00245746\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
NAD binding\vspace{3pt}}&\multirow{6}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
\vspace{3pt}}}\\\cline{1-3}
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
0.0025796\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
positive regulation of transcription\vspace{3pt}}&\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
regulation of transcription from RNA polymerase II promoter\vspace{3pt}}&\\\cline{1-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00273397\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
ubiquitin-protein ligase activity\vspace{3pt}}&\\\cline{1-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00308834\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
identical protein binding\vspace{3pt}}&\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00356939\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
signal transduction\vspace{3pt}}&\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.00362499\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
metabotropic glutamate receptor signaling pathway\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
1\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00369746\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
glycolysis\vspace{3pt}}&\multirow{11}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
\vspace{3pt}}}\\\cline{1-3}
\multirow{5}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
0.00383965\vspace{3pt}}}&\multirow{6}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
aldehyde dehydrogenase [NAD(P)+] activity\vspace{3pt}}&\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
histamine receptor activity\vspace{3pt}}&\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
interleukin-1 receptor activity\vspace{3pt}}&\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
membrane coat\vspace{3pt}}&\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
nucleoside transporter activity\vspace{3pt}}&\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00391116\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
soluble fraction\vspace{3pt}}&\\\cline{1-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0040154\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity\vspace{3pt}}&\\\cline{1-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00425207\vspace{3pt}}&\multirow{9}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
cell cycle\vspace{3pt}}&\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00504034\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
mitosis\vspace{3pt}}&\\\cline{1-1}\cline{3-3}
\multirow{4}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
0.00564318\vspace{3pt}}}&&\parbox{\wcC}{\vspace{3pt}\noindent
circulation\vspace{3pt}}&\\\cline{3-4}
&&\parbox{\wcC}{\vspace{3pt}\noindent
dopamine receptor activity\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
1\vspace{3pt}}\\\cline{3-4}
&&\parbox{\wcC}{\vspace{3pt}\noindent
ligand-dependent nuclear receptor activity\vspace{3pt}}&\multirow{4}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
\vspace{3pt}}}\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
positive regulation of I-kappaB kinase/NF-kappaB cascade\vspace{3pt}}&\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00614065\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
RNA polymerase II transcription factor activity\vspace{3pt}}&\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00664368\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
negative regulation of cell growth\vspace{3pt}}&\\\cline{1-1}\cline{3-4}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00670433\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
voltage-gated ion channel activity\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
1\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.00718696\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
regulation of transcription, DNA-dependent\vspace{3pt}}&\multirow{4}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
\vspace{3pt}}}\\\cline{1-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00726676\vspace{3pt}}&\multirow{8}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
multicellular organismal development\vspace{3pt}}&\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00759448\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
protein serine/threonine phosphatase activity\vspace{3pt}}&\\\cline{1-1}\cline{3-3}
\multirow{6}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
0.00774091\vspace{3pt}}}&&\parbox{\wcC}{\vspace{3pt}\noindent
acetyltransferase activity\vspace{3pt}}&\\\cline{3-4}
&&\parbox{\wcC}{\vspace{3pt}\noindent
electron carrier activity\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
1\vspace{3pt}}\\\cline{3-4}
&&\parbox{\wcC}{\vspace{3pt}\noindent
ER-Golgi intermediate compartment\vspace{3pt}}&\multirow{7}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
\vspace{3pt}}}\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
guanyl nucleotide binding\vspace{3pt}}&\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
positive regulation of body size\vspace{3pt}}&\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
retinoic acid metabolic process\vspace{3pt}}&\\\cline{1-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00803044\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
binding\vspace{3pt}}&\\\cline{1-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00833399\vspace{3pt}}&\multirow{4}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
regulation of transcription\vspace{3pt}}&\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00836988\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
intracellular\vspace{3pt}}&\\\cline{1-1}\cline{3-4}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00878703\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
nervous system development\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
1\vspace{3pt}}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00916333\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
visual perception\vspace{3pt}}&\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.00965867\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
mitochondrion\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
\vspace{3pt}}}\\\cline{1-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.00970846\vspace{3pt}}&\multirow{4}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
chromosome, pericentric region\vspace{3pt}}&\\\cline{1-1}\cline{3-4}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0100316\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
potassium ion binding\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
1\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
0.0101128\vspace{3pt}}}&&\parbox{\wcC}{\vspace{3pt}\noindent
anatomical structure morphogenesis\vspace{3pt}}&\multirow{8}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
\vspace{3pt}}}\\\cline{3-3}
&&\parbox{\wcC}{\vspace{3pt}\noindent
humoral immune response\vspace{3pt}}&\\\cline{1-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0105006\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
trypsin activity\vspace{3pt}}&\\\cline{1-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0107462\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
microtubule binding\vspace{3pt}}&\\\cline{1-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.01078\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Golgi stack\vspace{3pt}}&\\\cline{1-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0108714\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
nucleoplasm\vspace{3pt}}&\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0109032\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
endoplasmic reticulum\vspace{3pt}}&\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
0.0109353\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
calmodulin binding\vspace{3pt}}&\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
0.0111584\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
metabotropic glutamate, GABA-B-like receptor activity\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
1\vspace{3pt}}\\\hline
nd{longtable}

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.

 - Accession is the GO accession key. 

 - Part of neuralk circuitery.

- http://analysis.yellowcouch.org/