MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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p	description	Ratio	Accession	neuronal

Results: HTML CSV LaTeX

Showing element 51 to 100 of 239 in total

p	description	Ratio	neuronal
0.00245746	NAD binding	down	no value
0.0025796	positive regulation of transcription	up
	regulation of transcription from RNA polymerase II promoter
0.00273397	ubiquitin-protein ligase activity	down
0.00308834	identical protein binding	up
0.00356939	signal transduction
0.00362499	metabotropic glutamate receptor signaling pathway	down	1
0.00369746	glycolysis		no value
0.00383965	aldehyde dehydrogenase [NAD(P)+] activity	up
	histamine receptor activity
	interleukin-1 receptor activity
	membrane coat
	nucleoside transporter activity
0.00391116	soluble fraction
0.0040154	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	down
0.00425207	cell cycle	up
0.00504034	mitosis
0.00564318	circulation
	dopamine receptor activity		1
	ligand-dependent nuclear receptor activity		no value
	positive regulation of I-kappaB kinase/NF-kappaB cascade
0.00614065	RNA polymerase II transcription factor activity
0.00664368	negative regulation of cell growth
0.00670433	voltage-gated ion channel activity		1
0.00718696	regulation of transcription, DNA-dependent	down	no value
0.00726676	multicellular organismal development	up
0.00759448	protein serine/threonine phosphatase activity
0.00774091	acetyltransferase activity
	electron carrier activity		1
	ER-Golgi intermediate compartment		no value
	guanyl nucleotide binding
	positive regulation of body size
	retinoic acid metabolic process
0.00803044	binding	down
0.00833399	regulation of transcription	up
0.00836988	intracellular
0.00878703	nervous system development		1
0.00916333	visual perception
0.00965867	mitochondrion	down	no value
0.00970846	chromosome, pericentric region	up
0.0100316	potassium ion binding		1
0.0101128	anatomical structure morphogenesis		no value
	humoral immune response
0.0105006	trypsin activity	down
0.0107462	microtubule binding	up
0.01078	Golgi stack	down
0.0108714	nucleoplasm	up
0.0109032	endoplasmic reticulum
0.0109353	calmodulin binding
0.0111584	metabotropic glutamate, GABA-B-like receptor activity	down	1

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.