MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

Navigation/Query Panel:
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Ratio	p	description	Accession	neuronal

Results: HTML CSV LaTeX

Showing element 141 to 190 of 239 in total

Ratio  : up

p	description	neuronal
0.0202076	extracellular matrix binding	no value
	glyoxylate cycle
	interleukin-1 receptor complex
	interleukin-18 receptor complex
	leading edge cell differentiation
	leukocyte activation
	leukocyte adhesion
	male pronucleus
	methyl-CpG binding
	monoamine transporter activity
	oocyte differentiation
	osmosensory signaling pathway
	phosphatidylinositol-3,4,5-triphosphate binding
	positive regulation of receptor mediated endocytosis
	positive regulation of smooth muscle contraction
	positive regulation of vasoconstriction
	protein kinase C inhibitor activity
	protein phosphatase type 2A activity
	regulation of viral transcription
	RNA lariat debranching enzyme activity
	selenocysteine incorporation
	transcription from RNA polymerase III promoter
	transport vesicle
	tyrosine phosphorylation of STAT protein
	vitamin D receptor binding
	zygotic determination of anterior/posterior axis, embryo
0.023627	hormone activity
0.024391	protein complex assembly
0.0254395	integral to Golgi membrane
	response to drug
	transcription cofactor activity
0.0262113	anion transport
	neurotransmitter:sodium symporter activity	1
0.0280274	synapse
0.02908	calcium channel regulator activity
0.0322278	nucleotide binding	no value
0.0328763	ribonuclease activity
0.0335097	ubiquitin cycle
0.0338741	protein homodimerization activity
0.0340565	inner ear morphogenesis
0.0354267	lipid metabolic process
0.0368141	antiporter activity
	inorganic anion exchanger activity
	negative regulation of protein kinase activity
0.0369324	cell adhesion
0.037387	plasma membrane
0.0374953	transcription factor activity
0.0382916	transcription from RNA polymerase II promoter
0.0395988	7S RNA binding
	activation of MAPKK activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.