MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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p	Ratio	description	Accession	neuronal

Results: HTML CSV LaTeX

Showing element 141 to 190 of 239 in total

p	Ratio	description	neuronal
0.0202076	up	male pronucleus	no value
		methyl-CpG binding
		monoamine transporter activity
		oocyte differentiation
		osmosensory signaling pathway
		phosphatidylinositol-3,4,5-triphosphate binding
		positive regulation of receptor mediated endocytosis
		positive regulation of smooth muscle contraction
		positive regulation of vasoconstriction
		protein kinase C inhibitor activity
		protein phosphatase type 2A activity
		regulation of viral transcription
		RNA lariat debranching enzyme activity
		selenocysteine incorporation
		transcription from RNA polymerase III promoter
		transport vesicle
		tyrosine phosphorylation of STAT protein
		vitamin D receptor binding
		zygotic determination of anterior/posterior axis, embryo
0.0204393	down	proteolysis
0.0206183		microtubule-based movement
0.0216681		kinase activity
0.023627	up	hormone activity
0.024391		protein complex assembly
0.0254395		integral to Golgi membrane
		response to drug
		transcription cofactor activity
0.0262113		anion transport
		neurotransmitter:sodium symporter activity	1
0.0280274		synapse
0.028596	down	integrase activity	no value
0.02908	up	calcium channel regulator activity	1
0.0291865	down	DNA replication	no value
0.0322278	up	nucleotide binding
0.0328763		ribonuclease activity
0.0335097		ubiquitin cycle
0.0338741		protein homodimerization activity
0.0340565		inner ear morphogenesis
0.0350815	down	gamete generation
0.0354267	up	lipid metabolic process
0.0368141		antiporter activity
		inorganic anion exchanger activity
		negative regulation of protein kinase activity
0.0369324		cell adhesion
0.037387		plasma membrane
0.0374953		transcription factor activity
0.0377184	down	transferase activity
0.0382916	up	transcription from RNA polymerase II promoter
0.0395988		7S RNA binding
		activation of MAPKK activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.