MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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neuronal	description	p	Ratio	Accession

Results: HTML CSV LaTeX

Showing element 191 to 239 of 239 in total

neuronal	description	p	Ratio
no value	ribosome	0.0000251477	down
	RNA lariat debranching enzyme activity	0.0202076	up
	RNA polymerase II transcription factor activity	0.00614065
	RNA splicing	0.0000000131078
	selenocysteine incorporation	0.0202076
	signal transduction	0.00356939
	small conjugating protein ligase activity	0
	sodium:dicarboxylate symporter activity	0.0127396
	soluble fraction	0.00391116
	STAT protein nuclear translocation	0.0395988
	structural constituent of cell wall	0.00000824263
	structural constituent of ribosome	0.000000819712	down
	Toll binding	0.0395988	up
	transcription	0.000975592
	transcription cofactor activity	0.0254395
	transcription factor activity	0.0374953
	transcription from RNA polymerase II promoter	0.0382916
	transcription from RNA polymerase III promoter	0.0202076
	transcriptional activator activity	0.0470779
	transferase activity	0.0377184	down
	translation	0.00000618855
	transport vesicle	0.0202076	up
	trypsin activity	0.0105006	down
	tyrosine phosphorylation of STAT protein	0.0202076	up
	ubiquitin cycle	0.0335097
	ubiquitin ligase complex	0.000541705	down
	ubiquitin-protein ligase activity	0.00273397
	vitamin D receptor binding	0.0202076	up
	zinc ion binding	0.000654237	down
	zygotic determination of anterior/posterior axis, embryo	0.0202076	up
1	axon ensheathment	0.0395988
	calcium channel regulator activity	0.02908
	cannabinoid receptor activity	0.0395988
	detection of stimulus during sensory perception	0.0202076
	dopamine receptor activity	0.00564318
	electron carrier activity	0.00774091
	metabotropic glutamate receptor signaling pathway	0.00362499	down
	metabotropic glutamate, GABA-B-like receptor activity	0.0111584
	nervous system development	0.00878703	up
	neuropeptide hormone activity	0.00115531
	neuropeptide receptor activity	0.0395988
	neurotransmitter:sodium symporter activity	0.0262113
	olfactory receptor activity	0.000000227862	down
	potassium ion binding	0.0100316	up
	sensory perception	0.0197922	down
	sensory perception of sound	0.0159483	up
	synapse	0.0280274
	visual perception	0.00916333
	voltage-gated ion channel activity	0.00670433

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.