Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.


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neuronal description p Ratio Accession
Results: HTML CSV LaTeX Showing element 191 to 239 of 239 in total
neuronal
description
p
Ratio
no value ribosome 0.0000251477 down
RNA lariat debranching enzyme activity 0.0202076 up
RNA polymerase II transcription factor activity 0.00614065
RNA splicing 0.0000000131078
selenocysteine incorporation 0.0202076
signal transduction 0.00356939
small conjugating protein ligase activity 0
sodium:dicarboxylate symporter activity 0.0127396
soluble fraction 0.00391116
STAT protein nuclear translocation 0.0395988
structural constituent of cell wall 0.00000824263
structural constituent of ribosome 0.000000819712 down
Toll binding 0.0395988 up
transcription 0.000975592
transcription cofactor activity 0.0254395
transcription factor activity 0.0374953
transcription from RNA polymerase II promoter 0.0382916
transcription from RNA polymerase III promoter 0.0202076
transcriptional activator activity 0.0470779
transferase activity 0.0377184 down
translation 0.00000618855
transport vesicle 0.0202076 up
trypsin activity 0.0105006 down
tyrosine phosphorylation of STAT protein 0.0202076 up
ubiquitin cycle 0.0335097
ubiquitin ligase complex 0.000541705 down
ubiquitin-protein ligase activity 0.00273397
vitamin D receptor binding 0.0202076 up
zinc ion binding 0.000654237 down
zygotic determination of anterior/posterior axis, embryo 0.0202076 up
1 axon ensheathment 0.0395988
calcium channel regulator activity 0.02908
cannabinoid receptor activity 0.0395988
detection of stimulus during sensory perception 0.0202076
dopamine receptor activity 0.00564318
electron carrier activity 0.00774091
metabotropic glutamate receptor signaling pathway 0.00362499 down
metabotropic glutamate, GABA-B-like receptor activity 0.0111584
nervous system development 0.00878703 up
neuropeptide hormone activity 0.00115531
neuropeptide receptor activity 0.0395988
neurotransmitter:sodium symporter activity 0.0262113
olfactory receptor activity 0.000000227862 down
potassium ion binding 0.0100316 up
sensory perception 0.0197922 down
sensory perception of sound 0.0159483 up
synapse 0.0280274
visual perception 0.00916333
voltage-gated ion channel activity 0.00670433

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.

- http://analysis.yellowcouch.org/